Detailed information of TA system TA067899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2699613..2700292
• Replicon: chromosome
• Accession: NZ_CP017650
• Organism: Acinetobacter baumannii strain KAB05

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KAB05_RS12835
• Protein ID: WP_000838146.1
• Coordinates: 2700110..2700292 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KAB05_RS12830
• Protein ID: WP_000966688.1
• Coordinates: 2699613..2700017 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB05_RS12810	2696625..2697617	-	993	WP_000835645.1	KilA-N domain-containing protein	-
KAB05_RS19765	2697614..2697769	-	156	WP_001103649.1	Arc family DNA-binding protein	-
KAB05_RS12815	2697892..2698131	+	240	WP_000763623.1	Arc family DNA-binding protein	-
KAB05_RS12820	2698180..2698974	-	795	WP_000720608.1	hypothetical protein	-
KAB05_RS12825	2699006..2699329	-	324	WP_000523922.1	DUF4236 domain-containing protein	-
KAB05_RS19770	2699338..2699514	-	177	WP_014466185.1	hypothetical protein	-
KAB05_RS12830	2699613..2700017	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KAB05_RS12835	2700110..2700292	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KAB05_RS12840	2700618..2701133	-	516	WP_001185608.1	hypothetical protein	-
KAB05_RS12845	2701203..2702120	-	918	WP_000094250.1	hypothetical protein	-
KAB05_RS12850	2702173..2703327	-	1155	WP_070423368.1	phage tail protein	-
KAB05_RS12855	2703327..2703680	-	354	WP_015451444.1	hypothetical protein	-
KAB05_RS12860	2703776..2703994	-	219	WP_070423369.1	hypothetical protein	-
KAB05_RS12865	2703996..2704394	-	399	WP_001251850.1	hypothetical protein	-
KAB05_RS12870	2704396..2704764	-	369	WP_002055488.1	hypothetical protein	-
KAB05_RS12875	2704736..2705140	-	405	WP_000247948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2684046..2713445	29399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T67899 WP_000838146.1 NZ_CP017650:c2700292-2700110 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T67899 NZ_CP017650:c2700292-2700110 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT67899 WP_000966688.1 NZ_CP017650:c2700017-2699613 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT67899 NZ_CP017650:c2700017-2699613 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6