Detailed information of TA system TA067897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1249158..1249837
• Replicon: chromosome
• Accession: NZ_CP017648
• Organism: Acinetobacter baumannii strain KAB04

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KAB04_RS05965
• Protein ID: WP_000838146.1
• Coordinates: 1249158..1249340 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KAB04_RS05970
• Protein ID: WP_000966688.1
• Coordinates: 1249433..1249837 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB04_RS05930	1244556..1244960	+	405	WP_000248222.1	hypothetical protein	-
KAB04_RS05935	1244932..1245300	+	369	WP_070439903.1	hypothetical protein	-
KAB04_RS05940	1245302..1245700	+	399	WP_000178914.1	hypothetical protein	-
KAB04_RS05945	1245769..1246122	+	354	WP_000064602.1	hypothetical protein	-
KAB04_RS05950	1246122..1247276	+	1155	WP_070439831.1	phage tail protein	-
KAB04_RS05955	1247329..1248246	+	918	WP_000094270.1	hypothetical protein	-
KAB04_RS05960	1248317..1248832	+	516	WP_038346477.1	hypothetical protein	-
KAB04_RS05965	1249158..1249340	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KAB04_RS05970	1249433..1249837	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KAB04_RS20030	1249936..1250112	+	177	WP_014466185.1	hypothetical protein	-
KAB04_RS05975	1250121..1250444	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
KAB04_RS05980	1250476..1251270	+	795	WP_000720608.1	hypothetical protein	-
KAB04_RS05985	1251319..1251558	-	240	WP_000763623.1	Arc family DNA-binding protein	-
KAB04_RS20035	1251681..1251836	+	156	WP_001103649.1	Arc family DNA-binding protein	-
KAB04_RS05990	1251833..1252825	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1220070..1266124	46054

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T67897 WP_000838146.1 NZ_CP017648:1249158-1249340 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T67897 NZ_CP017648:1249158-1249340 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT67897 WP_000966688.1 NZ_CP017648:1249433-1249837 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT67897 NZ_CP017648:1249433-1249837 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6