Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2961797..2962448 Replicon chromosome
Accession NZ_CP017644
Organism Acinetobacter baumannii strain KAB02

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag KAB02_RS14175 Protein ID WP_000838146.1
Coordinates 2962266..2962448 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag KAB02_RS14170 Protein ID WP_000966689.1
Coordinates 2961797..2962201 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAB02_RS14155 2956830..2957171 - 342 WP_001281459.1 phage tail protein -
KAB02_RS14160 2957289..2961254 - 3966 WP_000191304.1 tape measure protein -
KAB02_RS14165 2961315..2961716 - 402 WP_000720591.1 hypothetical protein -
KAB02_RS14170 2961797..2962201 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KAB02_RS14175 2962266..2962448 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
KAB02_RS14180 2962779..2963312 - 534 WP_001185622.1 hypothetical protein -
KAB02_RS14185 2963357..2964286 - 930 WP_000094300.1 hypothetical protein -
KAB02_RS20110 2964571..2965661 + 1091 WP_085940413.1 IS4-like element ISAba1 family transposase -
KAB02_RS14200 2965797..2966195 - 399 WP_001132270.1 hypothetical protein -
KAB02_RS14205 2966197..2966565 - 369 WP_000539752.1 hypothetical protein -
KAB02_RS14210 2966537..2966941 - 405 WP_000248324.1 hypothetical protein -
KAB02_RS14215 2966950..2967318 - 369 WP_000524231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2940437..3001476 61039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T67892 WP_000838146.1 NZ_CP017644:c2962448-2962266 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T67892 NZ_CP017644:c2962448-2962266 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT67892 WP_000966689.1 NZ_CP017644:c2962201-2961797 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT67892 NZ_CP017644:c2962201-2961797 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References