Detailed information of TA system TA067889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 5711552..5712578
• Replicon: chromosome
• Accession: NZ_CP017641
• Organism: Fuerstia marisgermanicae strain NH11

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: Fuma_RS21285
• Protein ID: WP_077025893.1
• Coordinates: 5711552..5712118 (-)
• Length: 189 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: Fuma_RS21290
• Protein ID: WP_077025894.1
• Coordinates: 5712120..5712578 (-)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Fuma_RS21265	5707312..5707902	-	591	WP_077025889.1	recombinase family protein	-
Fuma_RS21270	5708129..5708785	+	657	WP_077025890.1	hypothetical protein	-
Fuma_RS21275	5709018..5710196	-	1179	WP_158521090.1	ATP-binding protein	-
Fuma_RS34905	5711020..5711292	+	273	WP_145944290.1	hypothetical protein	-
Fuma_RS21285	5711552..5712118	-	567	WP_077025893.1	PIN domain-containing protein	Toxin
Fuma_RS21290	5712120..5712578	-	459	WP_077025894.1	excisionase family DNA-binding protein	Antitoxin
Fuma_RS21295	5712831..5713787	+	957	WP_145944291.1	hypothetical protein	-
Fuma_RS21300	5713885..5714193	+	309	WP_077025896.1	hypothetical protein	-
Fuma_RS21305	5714193..5714381	+	189	WP_077025897.1	hypothetical protein	-
Fuma_RS21315	5715023..5715214	-	192	WP_077025899.1	hypothetical protein	-
Fuma_RS34910	5715425..5715673	+	249	WP_145944292.1	hypothetical protein	-
Fuma_RS21320	5715801..5716130	+	330	WP_083732610.1	HU family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-112)

Antitoxin

• Helix-turn-helix domain, group 17 (82-130)

Sequences

Toxin

Protein

• Length: 189 a.a.
• Molecular weight: 21619.69 Da
• Isoelectric Point: 5.8685

>T67889 WP_077025893.1 NZ_CP017641:c5712118-5711552 [Fuerstia marisgermanicae]
VAHFTALCDSCVLYPAPLRDLLMHLAMTGLFRAKWTAQIHDEWIQNVLKNRPDLSEERLRRTQQLMDSHVDGLVTGYDKL
IPTLSLPDPDDRHVLAAAIRSRADVIVTFNLKDFPAAVLSEFDIEAQHPDDFIHYQIGLNGDEVCEAARRQRASLKNPPY
SVDDFLACLEVQQLPKTVEYLRRRRDWI

Nucleotide

• Length: 567 bp

>T67889 NZ_CP017641:c5712118-5711552 [Fuerstia marisgermanicae]
GTGGCGCATTTCACGGCGTTGTGTGACTCGTGTGTGCTTTATCCGGCGCCATTGCGCGACCTGTTGATGCATCTGGCCAT
GACAGGATTGTTCCGCGCCAAATGGACGGCACAGATTCACGACGAATGGATTCAGAATGTCCTGAAGAATCGGCCGGACC
TCTCTGAAGAACGTTTGCGAAGAACTCAACAGCTGATGGATTCCCACGTCGATGGCCTGGTGACCGGCTACGATAAACTG
ATTCCAACACTCAGCCTTCCGGACCCGGACGACAGACACGTGCTTGCGGCGGCCATTCGTTCCCGCGCCGATGTGATTGT
AACGTTCAACCTAAAGGATTTTCCGGCGGCTGTGCTAAGTGAATTCGACATTGAAGCTCAGCACCCGGACGACTTTATTC
ATTATCAGATTGGCCTGAACGGTGACGAAGTCTGTGAAGCGGCCAGACGTCAACGCGCGTCGCTGAAGAATCCTCCGTAT
TCGGTCGACGATTTTCTGGCGTGCCTGGAAGTGCAGCAGCTTCCGAAGACCGTGGAGTATCTACGACGTCGACGCGATTG
GATCTAG

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 17289.05 Da
• Isoelectric Point: 8.0284

>AT67889 WP_077025894.1 NZ_CP017641:c5712578-5712120 [Fuerstia marisgermanicae]
MIDTIENLDTLSPDEFDAKQVSETSRQLSALLSKKRKRKNVQVTIDGEDCRIPAAALRMLKDIMVQLSLGNGVTLIPVHA
ELTTQEAADLLNVSRPYLVKLLEEQKLPFRLVGSHRRVLFRDLMKFKRQQDERRLKVLEEMAAEAQDAGLGY

Nucleotide

• Length: 459 bp

>AT67889 NZ_CP017641:c5712578-5712120 [Fuerstia marisgermanicae]
ATGATTGATACCATCGAAAACCTGGACACACTTTCTCCCGACGAATTCGACGCTAAACAGGTGTCCGAAACGAGTCGACA
GTTGTCCGCTTTGCTGTCAAAGAAACGAAAACGCAAGAACGTTCAGGTCACCATTGACGGTGAAGACTGCAGGATTCCGG
CGGCAGCTCTGCGGATGCTCAAAGATATCATGGTCCAGCTTTCCCTCGGCAACGGTGTCACACTGATTCCCGTGCATGCA
GAACTGACAACTCAGGAGGCGGCGGACCTGCTGAATGTGTCACGTCCGTATCTGGTGAAATTGCTGGAAGAACAAAAACT
TCCGTTCCGACTTGTGGGTTCTCATCGCAGAGTCCTGTTTCGGGACCTGATGAAATTCAAACGTCAGCAGGATGAACGAC
GGTTGAAGGTTCTGGAAGAAATGGCGGCGGAAGCTCAGGACGCAGGACTGGGATACTGA