Detailed information of TA system TA067887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 703902..704485
• Replicon: chromosome
• Accession: NZ_CP017639
• Organism: Corynebacterium sp. NML98-0116

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: BJP05_RS03030
• Protein ID: WP_070363457.1
• Coordinates: 703902..704195 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1F1YMH8
• Locus tag: BJP05_RS03035
• Protein ID: WP_070362126.1
• Coordinates: 704192..704485 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP05_RS03015	699944..701101	-	1158	WP_070362124.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-
BJP05_RS03025	701368..703671	-	2304	WP_070362125.1	DEAD/DEAH box helicase	-
BJP05_RS03030	703902..704195	+	294	WP_070363457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJP05_RS03035	704192..704485	+	294	WP_070362126.1	putative addiction module antidote protein	Antitoxin
BJP05_RS03040	704758..704964	+	207	WP_070362127.1	hypothetical protein	-
BJP05_RS03045	705017..705871	-	855	WP_070362128.1	DUF3037 domain-containing protein	-
BJP05_RS03050	705940..706719	-	780	WP_084028558.1	excalibur calcium-binding domain-containing protein	-
BJP05_RS03055	706780..707142	-	363	WP_168156173.1	type II toxin-antitoxin system death-on-curing family toxin	-
BJP05_RS03060	707154..707720	-	567	WP_070362131.1	SocA family protein	-
BJP05_RS03070	708023..709396	+	1374	WP_070362132.1	NAD-dependent succinate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	659413..737833	78420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-87)

Antitoxin

• Uncharacterized protein HI1420 (15-94)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10924.60 Da
• Isoelectric Point: 9.5376

>T67887 WP_070363457.1 NZ_CP017639:703902-704195 [Corynebacterium sp. NML98-0116]
MGVCRLFPVELKDKHAQRRILYAIARCEAHGTMIGDIKPVGEKVNEMRFHFGPGYRVYYTQLGAVTVFLLAGGDKSSQAK
DIRTAQQLAQQVREEQS

Nucleotide

• Length: 294 bp

>T67887 NZ_CP017639:703902-704195 [Corynebacterium sp. NML98-0116]
TTGGGTGTGTGCAGATTATTTCCAGTTGAGCTGAAAGACAAACATGCTCAGCGGCGCATTTTGTATGCAATAGCCCGATG
CGAAGCACACGGAACAATGATTGGAGACATCAAACCCGTTGGCGAGAAAGTGAACGAGATGAGATTTCATTTCGGGCCAG
GCTACCGGGTGTACTACACCCAACTAGGCGCAGTAACGGTTTTCCTACTGGCCGGAGGAGATAAATCCAGCCAGGCTAAA
GATATTCGAACCGCTCAACAGCTCGCACAACAGGTAAGGGAGGAACAGTCGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10578.05 Da
• Isoelectric Point: 7.0095

>AT67887 WP_070362126.1 NZ_CP017639:704192-704485 [Corynebacterium sp. NML98-0116]
VKEVTFSAFDASKYLDSQEAVNDYLAIALEDGDTKTVQVVLRDIARAHGMSQLAKETQLNRESLYKSLSKDGNPSFAAIT
KIMKALGLKITLATQNA

Nucleotide

• Length: 294 bp

>AT67887 NZ_CP017639:704192-704485 [Corynebacterium sp. NML98-0116]
GTGAAGGAAGTAACATTTTCAGCGTTCGATGCAAGCAAATATCTCGATAGCCAAGAAGCAGTGAACGATTACCTGGCTAT
CGCCCTCGAAGACGGTGATACGAAAACCGTACAGGTGGTGTTGCGTGACATTGCCAGGGCACACGGCATGAGCCAGCTCG
CTAAAGAAACTCAACTCAACCGTGAATCCCTTTACAAGTCACTGTCAAAAGACGGTAACCCGTCCTTTGCGGCTATCACG
AAAATCATGAAAGCCCTAGGGCTCAAAATAACTCTCGCTACACAAAATGCCTAG

Structures

Antitoxin

• AlphaFold DB: A0A1F1YMH8