Detailed information of TA system TA067886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 304352..304835
• Replicon: chromosome
• Accession: NZ_CP017639
• Organism: Corynebacterium sp. NML98-0116

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BJP05_RS10880
• Protein ID: WP_070975596.1
• Coordinates: 304572..304835 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1F1UQ19
• Locus tag: BJP05_RS01275
• Protein ID: WP_070361826.1
• Coordinates: 304352..304588 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP05_RS01255	300444..300977	+	534	WP_070361823.1	orotate phosphoribosyltransferase	-
BJP05_RS01260	300964..301629	+	666	WP_070361824.1	RNA methyltransferase	-
BJP05_RS01265	301642..302853	+	1212	WP_070361825.1	glycoside hydrolase family 76	-
BJP05_RS01270	302905..303939	+	1035	WP_070363426.1	class II fructose-bisphosphate aldolase	-
BJP05_RS01275	304352..304588	+	237	WP_070361826.1	ribbon-helix-helix protein, CopG family	Antitoxin
BJP05_RS10880	304572..304835	+	264	WP_070975596.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJP05_RS01280	305025..306197	+	1173	WP_070361827.1	aromatic acid exporter family protein	-
BJP05_RS01285	306194..307078	-	885	WP_070361828.1	hypothetical protein	-
BJP05_RS01290	307129..308418	+	1290	WP_070361829.1	adenylosuccinate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10126.77 Da
• Isoelectric Point: 11.5772

>T67886 WP_070975596.1 NZ_CP017639:304572-304835 [Corynebacterium sp. NML98-0116]
VAWQIEFSPRARKAVRRLDKQVQRRLFQVLGDLSRLNDPRVRGKALVGGMSGLWRWRIGDYRVIAEIQDDIVTVLVVDVG
HRGEIYR

Nucleotide

• Length: 264 bp

>T67886 NZ_CP017639:304572-304835 [Corynebacterium sp. NML98-0116]
GTGGCCTGGCAGATTGAGTTTTCGCCTAGGGCACGAAAGGCGGTGCGGCGGTTAGACAAGCAGGTACAGCGTCGGCTTTT
TCAAGTCTTGGGTGATTTGTCGCGGTTGAATGATCCACGCGTCCGCGGTAAAGCCCTTGTAGGTGGAATGTCAGGGTTGT
GGCGGTGGCGTATCGGGGACTATCGGGTAATTGCTGAGATTCAAGATGACATCGTGACGGTGTTGGTGGTTGATGTTGGG
CACCGTGGAGAAATTTATAGGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8854.98 Da
• Isoelectric Point: 4.2508

>AT67886 WP_070361826.1 NZ_CP017639:304352-304588 [Corynebacterium sp. NML98-0116]
MSGSVISLRMDEVQKRRLDELATKTGRPKAFYIREAIEAYLDDAEYIYELQAEAEAVRRGELETVTLDELKAECGLAD

Nucleotide

• Length: 237 bp

>AT67886 NZ_CP017639:304352-304588 [Corynebacterium sp. NML98-0116]
ATGAGTGGATCAGTGATTAGTTTGCGAATGGACGAAGTCCAGAAGCGTCGGCTTGACGAGCTTGCTACAAAGACAGGTAG
GCCAAAGGCGTTCTACATCCGTGAGGCAATTGAGGCCTATCTTGATGACGCTGAATACATCTACGAGCTTCAGGCTGAGG
CGGAAGCTGTTCGTAGGGGCGAGCTGGAAACTGTTACCCTCGATGAGCTAAAGGCCGAGTGTGGCCTGGCAGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1F1UQ19