Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 894027..894652 Replicon chromosome
Accession NZ_CP017638
Organism Dickeya dianthicola RNS04.9

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DDI_RS04365 Protein ID WP_009114000.1
Coordinates 894027..894230 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3A4CQB3
Locus tag DDI_RS04370 Protein ID WP_024104994.1
Coordinates 894284..894652 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDI_RS04335 889476..889814 + 339 WP_024104989.1 P-II family nitrogen regulator -
DDI_RS04340 889857..891149 + 1293 WP_024104990.1 ammonium transporter AmtB -
DDI_RS04345 891283..892146 - 864 WP_024104991.1 acyl-CoA thioesterase II -
DDI_RS04350 892418..892975 + 558 WP_024104992.1 YbaY family lipoprotein -
DDI_RS04355 893004..893333 - 330 WP_024104993.1 MGMT family protein -
DDI_RS04365 894027..894230 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DDI_RS04370 894284..894652 - 369 WP_024104994.1 Hha toxicity modulator TomB Antitoxin
DDI_RS04375 895161..895304 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
DDI_RS04380 895320..895571 - 252 WP_024104995.1 type B 50S ribosomal protein L31 -
DDI_RS04385 895742..898891 - 3150 WP_024104996.1 multidrug efflux RND transporter permease subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T67872 WP_009114000.1 NZ_CP017638:c894230-894027 [Dickeya dianthicola RNS04.9]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T67872 NZ_CP017638:c894230-894027 [Dickeya dianthicola RNS04.9]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT67872 WP_024104994.1 NZ_CP017638:c894652-894284 [Dickeya dianthicola RNS04.9]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT67872 NZ_CP017638:c894652-894284 [Dickeya dianthicola RNS04.9]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGATAGCAGTCGTAGCTGGGTGAATGACCCGACTTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCTGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGTAACTACGGTATAAATGACGCCGAGTTGCAGAAATGGCGAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0


Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CQB3

References