Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 692672..693198 Replicon chromosome
Accession NZ_CP017638
Organism Dickeya dianthicola RNS04.9

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4CNM8
Locus tag DDI_RS03405 Protein ID WP_024104817.1
Coordinates 692672..692977 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CA80
Locus tag DDI_RS03410 Protein ID WP_024104818.1
Coordinates 692980..693198 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDI_RS03380 687732..688751 + 1020 WP_024104816.1 NADP-dependent oxidoreductase -
DDI_RS03385 688952..689956 + 1005 WP_099327157.1 IS110 family transposase -
DDI_RS03390 690264..690467 + 204 Protein_654 transposase -
DDI_RS03395 690457..691076 - 620 Protein_655 transposase -
DDI_RS03400 691384..692388 - 1005 WP_099327158.1 IS110 family transposase -
DDI_RS03405 692672..692977 - 306 WP_024104817.1 type II toxin-antitoxin system toxin CcdB Toxin
DDI_RS03410 692980..693198 - 219 WP_024104818.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DDI_RS03415 693257..693583 - 327 Protein_659 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
DDI_RS21865 693575..693703 - 129 Protein_660 DUF4102 domain-containing protein -
DDI_RS03420 693811..693993 - 183 WP_024109619.1 hypothetical protein -
DDI_RS03425 694142..694858 - 717 WP_024104820.1 M48 family metallopeptidase -
DDI_RS03430 694858..697953 - 3096 WP_024104821.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 677192..706203 29011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11820.63 Da        Isoelectric Point: 4.6983

>T67870 WP_024104817.1 NZ_CP017638:c692977-692672 [Dickeya dianthicola RNS04.9]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T67870 NZ_CP017638:c692977-692672 [Dickeya dianthicola RNS04.9]
ATGCAATTCATTGTTTACCAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCAAAGCGGCGTATGGTCATTCCGCTTATAGAATCGCATCACCTGTCTGAGAAGGTGAATAAAACGCTGTTCCCTCAGA
TCCGGATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTTCCCGTTGAAGTTATTGGTGAAGAGCTC
GCGGAGCTTGGCGACTATGCGGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8191.17 Da        Isoelectric Point: 8.6383

>AT67870 WP_024104818.1 NZ_CP017638:c693198-692980 [Dickeya dianthicola RNS04.9]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT67870 NZ_CP017638:c693198-692980 [Dickeya dianthicola RNS04.9]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAACTATCAGATTCTGAGTGCTGCCGGAGTCAATATTTCTGGTCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGCAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCTGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4CNM8

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CA80

References