Detailed information of TA system TA067869

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 472712..473390
• Replicon: chromosome
• Accession: NZ_CP017638
• Organism: Dickeya dianthicola RNS04.9

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DDI_RS02370
• Protein ID: WP_024104636.1
• Coordinates: 472959..473390 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A3A4CJ89
• Locus tag: DDI_RS02365
• Protein ID: WP_024104635.1
• Coordinates: 472712..472978 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDI_RS02350	469807..470415	-	609	WP_024104632.1	HD domain-containing protein	-
DDI_RS02355	470677..471327	+	651	WP_024104633.1	hemolysin III family protein	-
DDI_RS02360	471418..472398	-	981	WP_024104634.1	tRNA-modifying protein YgfZ	-
DDI_RS02365	472712..472978	+	267	WP_024104635.1	FAD assembly factor SdhE	Antitoxin
DDI_RS02370	472959..473390	+	432	WP_024104636.1	protein YgfX	Toxin
DDI_RS02375	473485..474003	-	519	WP_024104637.1	flavodoxin FldB	-
DDI_RS02380	474132..475457	-	1326	WP_024104638.1	MHS family MFS transporter	-
DDI_RS02385	475730..476629	+	900	WP_024104639.1	site-specific tyrosine recombinase XerD	-
DDI_RS02390	476719..477435	+	717	WP_024104640.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16839.52 Da
• Isoelectric Point: 11.7737

>T67869 WP_024104636.1 NZ_CP017638:472959-473390 [Dickeya dianthicola RNS04.9]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWSDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIVRRPWVMRNGVLLSLRATNGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T67869 NZ_CP017638:472959-473390 [Dickeya dianthicola RNS04.9]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10471.02 Da
• Isoelectric Point: 6.0666

>AT67869 WP_024104635.1 NZ_CP017638:472712-472978 [Dickeya dianthicola RNS04.9]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKLHFIRLLQCDDPDLFNWLMNHGEPVDPALKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT67869 NZ_CP017638:472712-472978 [Dickeya dianthicola RNS04.9]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3A4CJ89