Detailed information of TA system TA067865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1105341..1105900
• Replicon: chromosome
• Accession: NZ_CP017636
• Organism: Vibrio vulnificus Env1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BJD94_RS20815
• Protein ID: WP_045594922.1
• Coordinates: 1105622..1105900 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2S3SYL7
• Locus tag: BJD94_RS20810
• Protein ID: WP_038963674.1
• Coordinates: 1105341..1105625 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJD94_RS20785	1100801..1101994	+	1194	WP_011082341.1	glycine C-acetyltransferase	-
BJD94_RS20790	1102066..1103091	+	1026	WP_197672410.1	L-threonine 3-dehydrogenase	-
BJD94_RS20795	1103171..1103671	-	501	WP_103154547.1	hypothetical protein	-
BJD94_RS20800	1103749..1104012	-	264	WP_017791548.1	hypothetical protein	-
BJD94_RS20805	1104252..1105061	-	810	WP_103154560.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
BJD94_RS20810	1105341..1105625	+	285	WP_038963674.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BJD94_RS20815	1105622..1105900	+	279	WP_045594922.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJD94_RS20820	1105918..1106040	-	123	WP_103154546.1	DUF3265 domain-containing protein	-
BJD94_RS20825	1106037..1106462	-	426	WP_017420108.1	hypothetical protein	-
BJD94_RS20830	1107385..1107900	-	516	WP_017420109.1	lipocalin family protein	-
BJD94_RS20835	1108031..1109110	-	1080	WP_045627862.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
BJD94_RS20840	1109294..1110022	-	729	WP_038969856.1	MipA/OmpV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10919.63 Da
• Isoelectric Point: 4.3430

>T67865 WP_045594922.1 NZ_CP017636:1105622-1105900 [Vibrio vulnificus Env1]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRCRLLIIPEISMVISYWVEGDIIRVL
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T67865 NZ_CP017636:1105622-1105900 [Vibrio vulnificus Env1]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCTGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTTTG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11081.45 Da
• Isoelectric Point: 9.2167

>AT67865 WP_038963674.1 NZ_CP017636:1105341-1105625 [Vibrio vulnificus Env1]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKILSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT67865 NZ_CP017636:1105341-1105625 [Vibrio vulnificus Env1]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAATATTATCTCACGATGCATGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S3SYL7