Detailed information of TA system TA067863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 795188..795753
• Replicon: chromosome
• Accession: NZ_CP017635
• Organism: Vibrio vulnificus Env1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X8U0A9
• Locus tag: BJD94_RS04745
• Protein ID: WP_029865673.1
• Coordinates: 795466..795753 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BJD94_RS04740
• Protein ID: WP_017420803.1
• Coordinates: 795188..795469 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJD94_RS04700	790431..790742	+	312	WP_038964949.1	antibiotic biosynthesis monooxygenase	-
BJD94_RS04705	790733..790867	+	135	WP_072601184.1	DUF3265 domain-containing protein	-
BJD94_RS04710	791239..792183	-	945	WP_038964128.1	IS110 family transposase	-
BJD94_RS04715	792380..792535	+	156	WP_103154943.1	DUF3265 domain-containing protein	-
BJD94_RS04725	792874..793001	+	128	Protein_884	DUF3265 domain-containing protein	-
BJD94_RS23515	794974..795108	+	135	Protein_886	DUF3265 domain-containing protein	-
BJD94_RS04740	795188..795469	+	282	WP_017420803.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BJD94_RS04745	795466..795753	+	288	WP_029865673.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJD94_RS04755	796258..796347	+	90	WP_193783778.1	DUF3265 domain-containing protein	-
BJD94_RS04760	796375..796782	+	408	Protein_890	GNAT family N-acetyltransferase	-
BJD94_RS04770	798039..798983	+	945	Protein_892	group II intron reverse transcriptase/maturase	-
BJD94_RS04780	799392..799511	+	120	Protein_893	DUF3265 domain-containing protein	-
BJD94_RS04785	799602..799835	+	234	WP_038940866.1	DUF2188 domain-containing protein	-
BJD94_RS04790	799861..799953	+	93	WP_193773869.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1	361742..900507	538765
	-	inside	IScluster/Tn	-	-	784954..802010	17056
	-	inside	Integron	-	-	690251..800877	110626

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10993.65 Da
• Isoelectric Point: 5.1098

>T67863 WP_029865673.1 NZ_CP017635:795466-795753 [Vibrio vulnificus Env1]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T67863 NZ_CP017635:795466-795753 [Vibrio vulnificus Env1]
ATGAAAGTAGTTTGGTCTCCTTTAGCGCTTCAAAAGCTAGGCGATGCAGCGGAGTTTATTTCTTTGGATAATCCATCTGC
GGCAGAAAAGTGGGTAAATGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATGCCCCATACGAACTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCATGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGCCAAATATTGTCTGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10354.90 Da
• Isoelectric Point: 7.0141

>AT67863 WP_017420803.1 NZ_CP017635:795188-795469 [Vibrio vulnificus Env1]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
ADARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT67863 NZ_CP017635:795188-795469 [Vibrio vulnificus Env1]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCGTTATCTGAATTTCGTGCAGGTGTAGCTTCTTACATAAAACAAAT
CAATGAGACTCGCCGTCCATTGGTCATTACACAACGTGGTAAAGGTGTTGCTGTTGTTCTTGACGTTGCAGAGTATGAAG
CAATGCAAGAGAAAATTGAATTACTAGAAGAAATGCGTACAGCTGAAGCTCAATTAGCTTCAGGTCTTGGTGTTTCCAAT
GCTGATGCTCGCGCTCAAGTATTGGGACGCATTAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A7X8U0A9