Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 788802..789568 Replicon chromosome
Accession NZ_CP017635
Organism Vibrio vulnificus Env1

Toxin (Protein)


Gene name - Uniprot ID A0A7Y4LNG0
Locus tag BJD94_RS04680 Protein ID WP_038940770.1
Coordinates 788802..789299 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag BJD94_RS04685 Protein ID WP_017420534.1
Coordinates 789296..789568 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD94_RS04635 783837..784451 + 615 WP_038964760.1 hypothetical protein -
BJD94_RS23505 784466..784558 + 93 WP_005445235.1 DUF3265 domain-containing protein -
BJD94_RS04645 784954..785898 - 945 WP_038964128.1 IS110 family transposase -
BJD94_RS04655 786581..786703 + 123 WP_080584369.1 DUF3265 domain-containing protein -
BJD94_RS04660 786741..786974 + 234 WP_000233292.1 hypothetical protein -
BJD94_RS04670 787511..788455 - 945 WP_038964128.1 IS110 family transposase -
BJD94_RS04675 788690..788779 + 90 WP_085050507.1 DUF3265 domain-containing protein -
BJD94_RS04680 788802..789299 - 498 WP_038940770.1 GNAT family N-acetyltransferase Toxin
BJD94_RS04685 789296..789568 - 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
BJD94_RS23510 789678..789770 + 93 WP_079741491.1 DUF3265 domain-containing protein -
BJD94_RS04695 789797..790285 + 489 WP_038964951.1 GNAT family N-acetyltransferase -
BJD94_RS04700 790431..790742 + 312 WP_038964949.1 antibiotic biosynthesis monooxygenase -
BJD94_RS04705 790733..790867 + 135 WP_072601184.1 DUF3265 domain-containing protein -
BJD94_RS04710 791239..792183 - 945 WP_038964128.1 IS110 family transposase -
BJD94_RS04715 792380..792535 + 156 WP_103154943.1 DUF3265 domain-containing protein -
BJD94_RS04725 792874..793001 + 128 Protein_884 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 361742..900507 538765
- inside IScluster/Tn - - 784954..802010 17056
- inside Integron - - 690251..800877 110626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18459.10 Da        Isoelectric Point: 8.0487

>T67862 WP_038940770.1 NZ_CP017635:c789299-788802 [Vibrio vulnificus Env1]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T67862 NZ_CP017635:c789299-788802 [Vibrio vulnificus Env1]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTACCCGATAAGTTACAAAAAAAACACCAA
TCCTCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT67862 WP_017420534.1 NZ_CP017635:c789568-789296 [Vibrio vulnificus Env1]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT67862 NZ_CP017635:c789568-789296 [Vibrio vulnificus Env1]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGATCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCCGCTGATCGATACGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y4LNG0

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References