Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 781796..782727 Replicon chromosome
Accession NZ_CP017635
Organism Vibrio vulnificus Env1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag BJD94_RS04615 Protein ID WP_038969990.1
Coordinates 782194..782727 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag BJD94_RS04610 Protein ID WP_072609754.1
Coordinates 781796..782197 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD94_RS04560 777686..778156 + 471 WP_103155416.1 metal ABC transporter ATPase -
BJD94_RS23500 778177..778295 + 119 Protein_854 DUF3265 domain-containing protein -
BJD94_RS04565 778317..778724 + 408 WP_026130484.1 hypothetical protein -
BJD94_RS04570 778761..778856 + 96 WP_072610044.1 DUF3265 domain-containing protein -
BJD94_RS04575 779204..779353 + 150 WP_103155415.1 DUF3265 domain-containing protein -
BJD94_RS04580 779356..779799 + 444 WP_017420781.1 GNAT family N-acetyltransferase -
BJD94_RS04585 779796..779917 + 122 Protein_859 DUF3265 domain-containing protein -
BJD94_RS04590 779933..780490 + 558 WP_038940636.1 hypothetical protein -
BJD94_RS04595 780483..780617 + 135 WP_103155200.1 DUF3265 domain-containing protein -
BJD94_RS04600 780633..781235 + 603 WP_017191312.1 class I SAM-dependent methyltransferase -
BJD94_RS04605 781704..781874 + 171 WP_103154885.1 DUF3265 domain-containing protein -
BJD94_RS04610 781796..782197 + 402 WP_072609754.1 DUF1778 domain-containing protein Antitoxin
BJD94_RS04615 782194..782727 + 534 WP_038969990.1 GNAT family N-acetyltransferase Toxin
BJD94_RS04620 782846..783163 + 318 WP_000640723.1 heavy metal-binding domain-containing protein -
BJD94_RS04625 783178..783270 + 93 WP_079750045.1 DUF3265 domain-containing protein -
BJD94_RS04630 783632..783754 + 123 WP_103155243.1 DUF3265 domain-containing protein -
BJD94_RS04635 783837..784451 + 615 WP_038964760.1 hypothetical protein -
BJD94_RS23505 784466..784558 + 93 WP_005445235.1 DUF3265 domain-containing protein -
BJD94_RS04645 784954..785898 - 945 WP_038964128.1 IS110 family transposase -
BJD94_RS04655 786581..786703 + 123 WP_080584369.1 DUF3265 domain-containing protein -
BJD94_RS04660 786741..786974 + 234 WP_000233292.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 361742..900507 538765
- inside IScluster/Tn - - 784954..802010 17056
- inside Integron - - 690251..800877 110626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(49-125)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20054.36 Da        Isoelectric Point: 9.6704

>T67861 WP_038969990.1 NZ_CP017635:782194-782727 [Vibrio vulnificus Env1]
VSWGKEFVELSKSKHDRNSFDCGEHELNAFIKTQAAKHMQAGISRTMVLPSAQPLINQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPVPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNG
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T67861 NZ_CP017635:782194-782727 [Vibrio vulnificus Env1]
GTGAGTTGGGGTAAAGAGTTCGTAGAACTTAGTAAATCAAAGCATGACCGCAACTCATTCGACTGTGGTGAGCATGAGTT
AAACGCATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCAAC
CACTGATAAATCAAAAGTTCGCTATTTGTGCATTTTATAGTGTTGCCCCGAGTTCAATTAGCCGAGAAACATTACCGGCA
CAACTAGCAAAGAAACTTCCTAGGTATCCAGTCCCTGTTTTTCTTTTGGCTCAATTAGCTGTGCACAAGGAGTTTCATGG
CTCTGGGCTCGGAAAGGTTAGTCTAATTCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGGGCATACGCAA
TTGTTGTGGACTGTCTGACAGATTCTGCACAAGCGTTCTACACGAAGTTCGGTTTTGAAGTCTTGTGTGAACATAATGGG
CGTATTCGTATGTTTTTACCGATGAAAACGGTAGAACAGCTTTTTAATCAATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14683.97 Da        Isoelectric Point: 5.6250

>AT67861 WP_072609754.1 NZ_CP017635:781796-782197 [Vibrio vulnificus Env1]
MRHSPLNAALYSLLLRKLSVQIECALSLHYNLSGYGINPYIGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKAKAPNQALLEAAKFTDESGIK

Download         Length: 402 bp

>AT67861 NZ_CP017635:781796-782197 [Vibrio vulnificus Env1]
ATGCGGCATTCACCCCTTAACGCGGCGTTATATTCTCTCTTGCTCCGTAAACTATCCGTACAAATTGAATGTGCTTTAAG
TTTGCACTATAATCTTTCAGGTTACGGAATAAATCCGTACATAGGAGGGGTTATGGCAACAGCACGTTTAGATATCCGCC
TTGATGAAGAGATCAAGGCAAAAGCCGAAAAAGCATCGGCTTTGCTTGGTTTGAAAAGTCTCACTGAATATGTAGTGAGG
CTTATGGACGAAGATGCGACTCACGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTCTTTGACGAGTTTAT
GGCTGCATGCAATAAAGCAAAAGCACCGAATCAAGCGTTGCTTGAAGCTGCCAAGTTTACAGATGAGAGTGGTATTAAGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References