Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 742759..743304 Replicon chromosome
Accession NZ_CP017635
Organism Vibrio vulnificus Env1

Toxin (Protein)


Gene name parE Uniprot ID A0A151KUE6
Locus tag BJD94_RS04220 Protein ID WP_038939651.1
Coordinates 742759..743055 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D0III5
Locus tag BJD94_RS04225 Protein ID WP_000557295.1
Coordinates 743062..743304 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD94_RS04170 737807..737929 + 123 WP_103155491.1 DUF3265 domain-containing protein -
BJD94_RS04175 737959..738432 + 474 WP_061051369.1 GNAT family N-acetyltransferase -
BJD94_RS23490 738408..738551 + 144 Protein_781 DUF3265 domain-containing protein -
BJD94_RS04185 738591..739010 + 420 WP_038940638.1 RDD family protein -
BJD94_RS04190 739028..739129 + 102 WP_103154941.1 DUF3265 domain-containing protein -
BJD94_RS04195 739215..740684 + 1470 WP_103154940.1 DUF2075 domain-containing protein -
BJD94_RS04200 740716..740808 + 93 WP_072612521.1 DUF3265 domain-containing protein -
BJD94_RS04205 741642..741770 + 129 WP_108064565.1 DUF3265 domain-containing protein -
BJD94_RS04210 742114..742242 + 129 WP_080586428.1 DUF3265 domain-containing protein -
BJD94_RS04215 742585..742707 + 123 WP_080584461.1 DUF3265 domain-containing protein -
BJD94_RS04220 742759..743055 - 297 WP_038939651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BJD94_RS04225 743062..743304 - 243 WP_000557295.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BJD94_RS04230 743917..744861 - 945 WP_038964128.1 IS110 family transposase -
BJD94_RS04235 745061..745183 + 123 Protein_792 DUF3265 domain-containing protein -
BJD94_RS04240 745191..745553 - 363 WP_108064552.1 glyoxalase -
BJD94_RS04245 745669..745770 + 102 WP_103155479.1 DUF3265 domain-containing protein -
BJD94_RS04250 745797..746285 + 489 WP_103155480.1 hypothetical protein -
BJD94_RS04255 746741..746892 + 152 Protein_796 DUF3265 domain-containing protein -
BJD94_RS04260 746879..747598 + 720 WP_103155481.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 361742..900507 538765
- flank IS/Tn - - 743917..744861 944
- inside Integron - - 690251..800877 110626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11278.93 Da        Isoelectric Point: 9.6269

>T67860 WP_038939651.1 NZ_CP017635:c743055-742759 [Vibrio vulnificus Env1]
MQKNKYKLSKLAQTHLQKIKNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T67860 NZ_CP017635:c743055-742759 [Vibrio vulnificus Env1]
ATGCAAAAGAATAAATATAAGCTAAGTAAATTAGCACAGACCCATTTACAAAAAATCAAAAACTATACCGTCAACAATTT
CTCTGAGATGCAATGGCGAAGCTACAAAGATACCTTACTAACAGGGTTTCAAATGCTCGCTGACAACCCAGCTGTTGGTC
GCAGTTGCGATGAGATATACCCAAGTGGTTTTTATTTCCCTGTGGGCAAGCATACCGCTTACTTTACAAAAGAAGATGGC
TTCATTTTAGTTGTTGCTGTACTCGGTCAATCACAACTTCCGCAGAACCACCTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9002.17 Da        Isoelectric Point: 4.7914

>AT67860 WP_000557295.1 NZ_CP017635:c743304-743062 [Vibrio vulnificus Env1]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL

Download         Length: 243 bp

>AT67860 NZ_CP017635:c743304-743062 [Vibrio vulnificus Env1]
ATGCACACATTAACAGCAAATGATGCCAAACGTAACTTTGGTGAGTTACTTCTGAGCGCTCAACGTGAGCCAGTGAAAAT
TAGCAAAAATAGCAAAGATGCCGTAGTTGTTATGTCGATTAAGGACTATGAAGAGCTGGAGGCAATGAAAACTGATTACC
TGAGACATTGTTTCGAGTCAGCTAAGCAAGACTTGGCACAAGGCAATGTGGTTGATGGTGAAGACTTTTTAAACGCCTTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151KUE6

Antitoxin

Source ID Structure
AlphaFold DB A0A151KU25

References