Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 681642..682207 Replicon chromosome
Accession NZ_CP017635
Organism Vibrio vulnificus Env1

Toxin (Protein)


Gene name relE Uniprot ID A0A7X8U0A9
Locus tag BJD94_RS03555 Protein ID WP_029865673.1
Coordinates 681920..682207 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3BLE1
Locus tag BJD94_RS03550 Protein ID WP_000086647.1
Coordinates 681642..681923 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD94_RS03495 676644..676808 + 165 WP_193783784.1 DUF3265 domain-containing protein -
BJD94_RS03500 677151..677279 + 129 WP_103154584.1 DUF3265 domain-containing protein -
BJD94_RS03510 677622..677744 + 123 WP_103154583.1 DUF3265 domain-containing protein -
BJD94_RS03515 677769..678809 + 1041 WP_103154582.1 GTP pyrophosphokinase -
BJD94_RS03520 678824..678916 + 93 WP_193783783.1 DUF3265 domain-containing protein -
BJD94_RS03530 679277..679399 + 123 WP_103155501.1 DUF3265 domain-containing protein -
BJD94_RS03535 679416..679937 + 522 WP_017420670.1 GrpB family protein -
BJD94_RS03540 680072..680938 + 867 WP_103155499.1 hypothetical protein -
BJD94_RS03550 681642..681923 + 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BJD94_RS03555 681920..682207 + 288 WP_029865673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BJD94_RS23460 682217..682345 + 129 WP_103155500.1 DUF3265 domain-containing protein -
BJD94_RS03570 682689..682811 + 123 WP_080584369.1 DUF3265 domain-containing protein -
BJD94_RS03575 683250..683585 + 336 WP_108064548.1 hypothetical protein -
BJD94_RS03585 684514..684648 + 135 WP_103155377.1 DUF3265 domain-containing protein -
BJD94_RS03590 684652..685122 + 471 WP_103155376.1 hypothetical protein -
BJD94_RS03595 685145..685237 + 93 WP_079720568.1 DUF3265 domain-containing protein -
BJD94_RS03600 685262..686212 + 951 WP_199909381.1 DUF4268 domain-containing protein -
BJD94_RS03605 686227..686319 + 93 WP_079767277.1 DUF3265 domain-containing protein -
BJD94_RS03610 686680..686802 + 123 WP_072599326.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 361742..900507 538765
- inside Integron - - 611180..687587 76407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.65 Da        Isoelectric Point: 5.1098

>T67858 WP_029865673.1 NZ_CP017635:681920-682207 [Vibrio vulnificus Env1]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T67858 NZ_CP017635:681920-682207 [Vibrio vulnificus Env1]
ATGAAAGTAGTTTGGTCTCCATTAGCGCTTCAGAAGCTAGGCGATGCAGCGGAGTTTATTTCTTTGGATAATCCATCTGC
GGCAGAAAAGTGGGTAAATGAAGTTTTTGATAAAACCGAACTACTTGGAAGCATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATGCCCCATACGAACTATCGTGAAATCATCTTTGGTCACTATCGGATTATCTACAGCTTAAGTCACGAAATCCGCGTG
CTAACAGTTCGTAATTGTCGCCAAATACTGTCTGAAGATGACGTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10398.91 Da        Isoelectric Point: 5.8650

>AT67858 WP_000086647.1 NZ_CP017635:681642-681923 [Vibrio vulnificus Env1]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Download         Length: 282 bp

>AT67858 NZ_CP017635:681642-681923 [Vibrio vulnificus Env1]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCGTTATCTGAATTTCGTGCAGGTGTTGCTTCTTACATCAAACAAAT
CAATGAGACTCGCCGTCCATTGGTCATTACACAGCGTGGTAAAGGTGTTGCTGTTGTTCTTGATGTTGCAGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTAGAAGAAATGCGCACAGCTGAAGCTCAATTAGCTTCAGGCCTTGGTGTTTCCAAT
GATGATGCTCGTGCTCAAGTACTGGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0A9

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G0X0

References