Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4888220..4889208 Replicon chromosome
Accession NZ_CP017631
Organism Escherichia coli strain SLK172

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag BJJ90_RS26685 Protein ID WP_014640052.1
Coordinates 4888220..4888606 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0A1AFM1
Locus tag BJJ90_RS26690 Protein ID WP_000458583.1
Coordinates 4888636..4889208 (-) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ90_RS26640 4883690..4884226 + 537 WP_000008232.1 5'-deoxynucleotidase -
BJJ90_RS26645 4884217..4884567 + 351 WP_075362715.1 Eae protein -
BJJ90_RS26650 4884564..4884854 + 291 WP_069723346.1 DUF4752 family protein -
BJJ90_RS26655 4884851..4885534 + 684 WP_075362716.1 hypothetical protein -
BJJ90_RS26660 4885531..4886334 + 804 WP_075362717.1 ead/Ea22-like family protein -
BJJ90_RS26665 4886336..4886545 + 210 WP_000951717.1 hypothetical protein -
BJJ90_RS26670 4886542..4887069 + 528 WP_075362718.1 DUF551 domain-containing protein -
BJJ90_RS26675 4887069..4887641 + 573 WP_069723195.1 3'-5' exoribonuclease -
BJJ90_RS26680 4887678..4887959 + 282 WP_001093918.1 pyocin activator PrtN family protein -
BJJ90_RS33685 4888007..4888180 - 174 WP_000390072.1 hypothetical protein -
BJJ90_RS26685 4888220..4888606 - 387 WP_014640052.1 hypothetical protein Toxin
BJJ90_RS26690 4888636..4889208 - 573 WP_000458583.1 SocA family protein Antitoxin
BJJ90_RS26695 4889444..4889566 - 123 WP_001300034.1 hypothetical protein -
BJJ90_RS26700 4889927..4890919 - 993 WP_000912575.1 DUF2713 family protein -
BJJ90_RS26705 4891237..4891752 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
BJJ90_RS26710 4891794..4892003 - 210 WP_001030593.1 CsbD family protein -
BJJ90_RS26715 4892119..4893444 - 1326 WP_001326646.1 MATE family efflux transporter DinF -
BJJ90_RS26720 4893517..4894125 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4838743..4894125 55382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T67843 WP_014640052.1 NZ_CP017631:c4888606-4888220 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T67843 NZ_CP017631:c4888606-4888220 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21956.30 Da        Isoelectric Point: 6.0283

>AT67843 WP_000458583.1 NZ_CP017631:c4889208-4888636 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT67843 NZ_CP017631:c4889208-4888636 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AFM1

References