Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4737983..4738818 Replicon chromosome
Accession NZ_CP017631
Organism Escherichia coli strain SLK172

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag BJJ90_RS25820 Protein ID WP_000854821.1
Coordinates 4738441..4738818 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0D0LUA6
Locus tag BJJ90_RS25815 Protein ID WP_001285613.1
Coordinates 4737983..4738351 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ90_RS25790 4735382..4735615 + 234 WP_001117568.1 DUF905 family protein -
BJJ90_RS25795 4735705..4736523 + 819 WP_042634191.1 DUF945 domain-containing protein -
BJJ90_RS25800 4736615..4737097 + 483 WP_000206657.1 antirestriction protein -
BJJ90_RS25805 4737113..4737589 + 477 WP_001384108.1 RadC family protein -
BJJ90_RS25810 4737682..4737903 + 222 WP_000692350.1 DUF987 domain-containing protein -
BJJ90_RS25815 4737983..4738351 + 369 WP_001285613.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BJJ90_RS25820 4738441..4738818 + 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
BJJ90_RS33045 4738815..4739012 + 198 Protein_4586 hypothetical protein -
BJJ90_RS33050 4739040..4739237 + 198 WP_085949090.1 DUF957 domain-containing protein -
BJJ90_RS25830 4739322..4740164 + 843 WP_001280493.1 DUF4942 domain-containing protein -
BJJ90_RS25840 4740912..4742450 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T67841 WP_000854821.1 NZ_CP017631:4738441-4738818 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T67841 NZ_CP017631:4738441-4738818 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13636.42 Da        Isoelectric Point: 6.0618

>AT67841 WP_001285613.1 NZ_CP017631:4737983-4738351 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQTFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT67841 NZ_CP017631:4737983-4738351 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGACCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0LUA6

References