Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4508729..4509527 Replicon chromosome
Accession NZ_CP017631
Organism Escherichia coli strain SLK172

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0V7WHV8
Locus tag BJJ90_RS24475 Protein ID WP_001506713.1
Coordinates 4508729..4509106 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1E5M1V9
Locus tag BJJ90_RS24480 Protein ID WP_052913677.1
Coordinates 4509153..4509527 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ90_RS24440 4503944..4505050 + 1107 WP_001353974.1 N-acetylneuraminate epimerase -
BJJ90_RS24445 4505115..4506095 + 981 WP_001295601.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BJJ90_RS24450 4506103..4506753 - 651 WP_001037966.1 HNH endonuclease -
BJJ90_RS33510 4507798..4507956 - 159 WP_001467148.1 hypothetical protein -
BJJ90_RS24465 4508035..4508232 - 198 WP_000839249.1 DUF957 domain-containing protein -
BJJ90_RS24470 4508244..4508732 - 489 WP_001470575.1 hypothetical protein -
BJJ90_RS24475 4508729..4509106 - 378 WP_001506713.1 TA system toxin CbtA family protein Toxin
BJJ90_RS24480 4509153..4509527 - 375 WP_052913677.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BJJ90_RS24490 4509690..4509911 - 222 WP_000692311.1 DUF987 domain-containing protein -
BJJ90_RS24495 4509974..4510450 - 477 WP_069723416.1 RadC family protein -
BJJ90_RS24500 4510466..4510939 - 474 WP_001368734.1 antirestriction protein -
BJJ90_RS24505 4511033..4511278 - 246 WP_001164975.1 hypothetical protein -
BJJ90_RS24510 4511278..4511829 - 552 Protein_4349 DUF945 domain-containing protein -
BJJ90_RS24515 4511839..4512276 - 438 Protein_4350 DDE-type integrase/transposase/recombinase -
BJJ90_RS24530 4512330..4513543 + 1214 WP_173662723.1 IS3 family transposase -
BJJ90_RS24540 4513586..4514083 - 498 Protein_4352 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimE / fimB 4500079..4514083 14004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.26 Da        Isoelectric Point: 7.8045

>T67840 WP_001506713.1 NZ_CP017631:c4509106-4508729 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR

Download         Length: 378 bp

>T67840 NZ_CP017631:c4509106-4508729 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACATAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13676.47 Da        Isoelectric Point: 6.3139

>AT67840 WP_052913677.1 NZ_CP017631:c4509527-4509153 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT67840 NZ_CP017631:c4509527-4509153 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V7WHV8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5M1V9

References