Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3395663..3396503 Replicon chromosome
Accession NZ_CP017631
Organism Escherichia coli strain SLK172

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag BJJ90_RS18405 Protein ID WP_000854686.1
Coordinates 3395663..3396046 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag BJJ90_RS18410 Protein ID WP_001285602.1
Coordinates 3396123..3396503 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ90_RS18370 3392340..3393044 + 705 WP_001241676.1 leucyl/phenylalanyl-tRNA--protein transferase -
BJJ90_RS18380 3393329..3393547 + 219 WP_001040187.1 translation initiation factor IF-1 -
BJJ90_RS18390 3394037..3394879 - 843 WP_001274547.1 DUF4942 domain-containing protein -
BJJ90_RS18395 3394964..3395161 - 198 WP_000839253.1 DUF957 domain-containing protein -
BJJ90_RS18400 3395178..3395666 - 489 WP_001054233.1 hypothetical protein -
BJJ90_RS18405 3395663..3396046 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
BJJ90_RS18410 3396123..3396503 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BJJ90_RS18415 3396553..3397197 - 645 WP_000086748.1 hypothetical protein -
BJJ90_RS18420 3397216..3397437 - 222 WP_069723389.1 DUF987 domain-containing protein -
BJJ90_RS18425 3397524..3397922 - 399 WP_069723390.1 RadC family protein -
BJJ90_RS18430 3397938..3398423 - 486 WP_069723391.1 antirestriction protein -
BJJ90_RS18435 3398515..3399333 - 819 WP_024220054.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T67835 WP_000854686.1 NZ_CP017631:c3396046-3395663 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T67835 NZ_CP017631:c3396046-3395663 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT67835 WP_001285602.1 NZ_CP017631:c3396503-3396123 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT67835 NZ_CP017631:c3396503-3396123 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References