Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3176160..3176995 Replicon chromosome
Accession NZ_CP017631
Organism Escherichia coli strain SLK172

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L6W3P3
Locus tag BJJ90_RS17280 Protein ID WP_075362639.1
Coordinates 3176160..3176537 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L6W4Z7
Locus tag BJJ90_RS17285 Protein ID WP_070749977.1
Coordinates 3176627..3176995 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ90_RS17240 3171167..3171658 - 492 WP_001300785.1 DUF1097 domain-containing protein -
BJJ90_RS17245 3171760..3172314 - 555 WP_001001902.1 molecular chaperone YcdY -
BJJ90_RS17250 3172338..3173075 - 738 WP_000283664.1 zinc-binding phosphatase -
BJJ90_RS17255 3173130..3174068 - 939 WP_000351315.1 glyoxylate/hydroxypyruvate reductase GhrA -
BJJ90_RS17265 3174539..3175381 - 843 WP_075362638.1 DUF4942 domain-containing protein -
BJJ90_RS17270 3175466..3175663 - 198 WP_072643848.1 DUF957 domain-containing protein -
BJJ90_RS17275 3175675..3176163 - 489 WP_039022338.1 hypothetical protein -
BJJ90_RS17280 3176160..3176537 - 378 WP_075362639.1 TA system toxin CbtA family protein Toxin
BJJ90_RS17285 3176627..3176995 - 369 WP_070749977.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BJJ90_RS17290 3177045..3177689 - 645 WP_039025881.1 hypothetical protein -
BJJ90_RS17295 3177704..3177925 - 222 WP_000692312.1 DUF987 domain-containing protein -
BJJ90_RS17300 3177994..3178470 - 477 WP_001186770.1 RadC family protein -
BJJ90_RS17305 3178486..3178959 - 474 WP_075362640.1 antirestriction protein -
BJJ90_RS17315 3179301..3180119 - 819 WP_075362641.1 DUF945 domain-containing protein -
BJJ90_RS33430 3180213..3180391 + 179 Protein_3089 hypothetical protein -
BJJ90_RS17330 3180530..3180943 - 414 WP_000789536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3181260..3182240 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14112.20 Da        Isoelectric Point: 8.2962

>T67834 WP_075362639.1 NZ_CP017631:c3176537-3176160 [Escherichia coli]
MKTLPDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T67834 NZ_CP017631:c3176537-3176160 [Escherichia coli]
ATGAAAACATTACCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13860.63 Da        Isoelectric Point: 6.3177

>AT67834 WP_070749977.1 NZ_CP017631:c3176995-3176627 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQVFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT67834 NZ_CP017631:c3176995-3176627 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCATTTGGACCAGGTCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6W3P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6W4Z7

References