Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1959003..1959834 Replicon chromosome
Accession NZ_CP017631
Organism Escherichia coli strain SLK172

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag BJJ90_RS10285 Protein ID WP_000854814.1
Coordinates 1959003..1959377 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag BJJ90_RS10290 Protein ID WP_001285585.1
Coordinates 1959466..1959834 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJJ90_RS10250 1954399..1955565 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BJJ90_RS10255 1955684..1956157 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
BJJ90_RS10260 1956355..1957413 + 1059 WP_001200891.1 FUSC family protein -
BJJ90_RS10265 1957585..1957914 + 330 WP_000450409.1 DUF496 family protein -
BJJ90_RS10270 1958015..1958197 - 183 WP_001016348.1 hypothetical protein -
BJJ90_RS31930 1958269..1958397 + 129 Protein_1843 transposase domain-containing protein -
BJJ90_RS33835 1958686..1958799 - 114 WP_032154230.1 DUF957 domain-containing protein -
BJJ90_RS10280 1958812..1959006 - 195 WP_000988600.1 hypothetical protein -
BJJ90_RS10285 1959003..1959377 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
BJJ90_RS10290 1959466..1959834 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BJJ90_RS10295 1959908..1960129 - 222 WP_000692323.1 DUF987 domain-containing protein -
BJJ90_RS10300 1960192..1960668 - 477 WP_001186773.1 RadC family protein -
BJJ90_RS10305 1960684..1961163 - 480 WP_000860076.1 antirestriction protein -
BJJ90_RS10310 1961245..1962063 - 819 WP_001234629.1 DUF945 domain-containing protein -
BJJ90_RS10320 1962163..1962396 - 234 WP_001119729.1 DUF905 family protein -
BJJ90_RS10325 1962475..1962930 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T67818 WP_000854814.1 NZ_CP017631:c1959377-1959003 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T67818 NZ_CP017631:c1959377-1959003 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT67818 WP_001285585.1 NZ_CP017631:c1959834-1959466 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT67818 NZ_CP017631:c1959834-1959466 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References