Detailed information of TA system TA067802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 5663492..5664107
• Replicon: chromosome
• Accession: NZ_CP017599
• Organism: Moorea producens PAL-8-15-08-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1D8TV61
• Locus tag: BJP34_RS20700
• Protein ID: WP_070393977.1
• Coordinates: 5663718..5664107 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1D8TV64
• Locus tag: BJP34_RS20695
• Protein ID: WP_070393976.1
• Coordinates: 5663492..5663716 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP34_RS20660	5658505..5658717	+	213	WP_070393970.1	hypothetical protein	-
BJP34_RS20665	5658839..5659072	-	234	WP_070393971.1	hypothetical protein	-
BJP34_RS20670	5659318..5661129	-	1812	WP_083305276.1	asparaginase	-
BJP34_RS20675	5661375..5661581	+	207	WP_070393973.1	type II toxin-antitoxin system HicB family antitoxin	-
BJP34_RS20680	5661912..5662340	+	429	WP_070396790.1	DUF29 domain-containing protein	-
BJP34_RS20685	5662757..5662918	+	162	WP_083305643.1	anacyclamide/piricyclamide family prenylated cyclic peptide	-
BJP34_RS20690	5662931..5663311	-	381	WP_149031093.1	hypothetical protein	-
BJP34_RS20695	5663492..5663716	+	225	WP_070393976.1	DUF2281 domain-containing protein	Antitoxin
BJP34_RS20700	5663718..5664107	+	390	WP_070393977.1	type II toxin-antitoxin system VapC family toxin	Toxin
BJP34_RS37290	5664454..5664615	+	162	WP_083305277.1	anacyclamide/piricyclamide family prenylated cyclic peptide	-
BJP34_RS20705	5664803..5665108	+	306	WP_149031094.1	hypothetical protein	-
BJP34_RS46590	5665233..5665763	-	531	WP_202972000.1	hypothetical protein	-
BJP34_RS20715	5665756..5666688	+	933	WP_083305278.1	GNAT family N-acetyltransferase	-
BJP34_RS20720	5667212..5667781	+	570	WP_070393979.1	Uma2 family endonuclease	-
BJP34_RS20725	5668063..5668512	+	450	WP_070393980.1	DUF29 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (4-128)

Antitoxin

• Domain of unknown function DUF2281 (7-73)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14991.52 Da
• Isoelectric Point: 8.4495

>T67802 WP_070393977.1 NZ_CP017599:5663718-5664107 [Moorea producens PAL-8-15-08-1]
IKALLDTNAFLWYLLGDTRLSIKVKGIIDTQTNLYFSIVSLWEISIKINIGKLQINRPIGDLFQELQSTNIKLLPILDKD
IELYSALPFPSNHRDPFDRRLIVQAINHSLILISRDVKFDAYPIQRLWD

Nucleotide

• Length: 390 bp

>T67802 NZ_CP017599:5663718-5664107 [Moorea producens PAL-8-15-08-1]
ATTAAAGCTCTTCTCGATACTAATGCTTTTCTTTGGTATTTACTAGGTGATACTCGTCTATCGATTAAAGTCAAGGGTAT
TATTGATACCCAAACAAACCTGTATTTTAGTATTGTTAGCCTTTGGGAAATTTCTATTAAAATTAATATTGGTAAGTTGC
AAATTAATCGACCTATTGGAGATTTATTTCAAGAATTGCAATCTACCAATATTAAACTATTACCCATTCTCGATAAAGAT
ATTGAGTTATATTCAGCACTTCCTTTTCCGTCGAATCATCGCGACCCCTTTGATAGAAGGTTAATTGTTCAAGCTATCAA
TCACTCTCTTATTTTAATTAGTAGAGATGTCAAGTTTGATGCTTATCCAATTCAAAGGTTATGGGATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8645.60 Da
• Isoelectric Point: 4.1666

>AT67802 WP_070393976.1 NZ_CP017599:5663492-5663716 [Moorea producens PAL-8-15-08-1]
MNTELALWKVVISLPEHLKRELLHYADYLRENYPNNTQSDQEKIGTTHGYGSWAGQIIMSDDFDEPLEDLAEYM

Nucleotide

• Length: 225 bp

>AT67802 NZ_CP017599:5663492-5663716 [Moorea producens PAL-8-15-08-1]
ATGAATACTGAGTTAGCCTTATGGAAAGTCGTTATTAGTCTGCCTGAACATCTCAAGAGGGAACTATTGCATTATGCAGA
CTATTTACGAGAAAACTATCCAAATAATACACAATCTGATCAGGAAAAGATAGGAACCACTCACGGTTATGGTAGTTGGG
CAGGTCAAATCATTATGTCAGATGATTTTGATGAACCATTAGAAGATTTGGCGGAATATATGTAA

Structures

Toxin

• AlphaFold DB: A0A1D8TV61

Antitoxin

• AlphaFold DB: A0A1D8TV64