Detailed information of TA system TA067800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2200403..2200809
• Replicon: chromosome
• Accession: NZ_CP017599
• Organism: Moorea producens PAL-8-15-08-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BJP34_RS08555
• Protein ID: WP_070396562.1
• Coordinates: 2200612..2200809 (-)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1D8TPC1
• Locus tag: BJP34_RS08550
• Protein ID: WP_070391980.1
• Coordinates: 2200403..2200612 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP34_RS08490	2195540..2195842	-	303	WP_070391969.1	helix-turn-helix domain-containing protein	-
BJP34_RS36360	2195835..2195972	-	138	Protein_1912	type II toxin-antitoxin system RelE/ParE family toxin	-
BJP34_RS08495	2196028..2196405	-	378	WP_070391970.1	type II toxin-antitoxin system VapC family toxin	-
BJP34_RS08500	2196395..2196631	-	237	WP_202972133.1	hypothetical protein	-
BJP34_RS08505	2196872..2197306	-	435	Protein_1915	tetratricopeptide repeat protein	-
BJP34_RS08510	2197342..2197575	+	234	WP_070391973.1	transcriptional regulator	-
BJP34_RS42760	2197591..2197737	+	147	WP_158517089.1	hypothetical protein	-
BJP34_RS08515	2197843..2198211	+	369	WP_070391974.1	GIY-YIG nuclease family protein	-
BJP34_RS08520	2198208..2198438	+	231	WP_070391975.1	hypothetical protein	-
BJP34_RS08525	2198492..2198845	-	354	WP_070396561.1	hypothetical protein	-
BJP34_RS08530	2198926..2199366	+	441	WP_149030866.1	hypothetical protein	-
BJP34_RS08535	2199447..2199794	-	348	WP_070391977.1	XisI protein	-
BJP34_RS08545	2199970..2200311	-	342	WP_070391979.1	XisI protein	-
BJP34_RS08550	2200403..2200612	-	210	WP_070391980.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BJP34_RS08555	2200612..2200809	-	198	WP_070396562.1	type II toxin-antitoxin system HicA family toxin	Toxin
BJP34_RS39105	2201601..2201933	+	333	WP_149030867.1	hypothetical protein	-
BJP34_RS08560	2202004..2202492	-	489	WP_083305058.1	response regulator transcription factor	-
BJP34_RS42765	2202689..2202841	-	153	WP_158517090.1	hypothetical protein	-
BJP34_RS08570	2203131..2204126	-	996	WP_202972078.1	hypothetical protein	-
BJP34_RS08575	2204371..2205243	+	873	WP_070391982.1	DUF4255 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2186431..2220617	34186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7351.46 Da
• Isoelectric Point: 10.4725

>T67800 WP_070396562.1 NZ_CP017599:c2200809-2200612 [Moorea producens PAL-8-15-08-1]
MKVKEVIKVLEGDGWYLARTRGSHRQYKHPSKSGTVTVSGKSSVEVPIGTLKNIWRQAQIEEDKI

Nucleotide

• Length: 198 bp

>T67800 NZ_CP017599:c2200809-2200612 [Moorea producens PAL-8-15-08-1]
ATGAAAGTCAAAGAAGTGATTAAAGTGTTAGAGGGAGATGGCTGGTATCTTGCTAGGACAAGAGGAAGTCATAGACAATA
TAAGCATCCCTCAAAGTCTGGTACGGTAACAGTATCGGGTAAATCAAGTGTTGAGGTTCCAATTGGGACTCTTAAAAATA
TATGGCGACAAGCTCAAATAGAGGAGGACAAAATTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7552.67 Da
• Isoelectric Point: 4.1012

>AT67800 WP_070391980.1 NZ_CP017599:c2200612-2200403 [Moorea producens PAL-8-15-08-1]
MRYAVVIEKGKNSYGAYVPDLPGCVAVAETLEEVKQLITEAVMFHLEGLKEDGLTAPESVSFCEYIEVA

Nucleotide

• Length: 210 bp

>AT67800 NZ_CP017599:c2200612-2200403 [Moorea producens PAL-8-15-08-1]
ATGCGCTATGCAGTTGTTATTGAAAAAGGAAAAAATAGCTACGGTGCTTATGTTCCCGATCTTCCTGGGTGTGTTGCGGT
GGCAGAAACATTAGAAGAGGTTAAACAATTAATAACTGAGGCAGTGATGTTTCATTTGGAAGGATTAAAAGAAGATGGAT
TAACTGCTCCTGAATCAGTGTCATTCTGTGAGTATATTGAGGTGGCTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1D8TPC1