Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3800982..3801511 Replicon chromosome
Accession NZ_CP017597
Organism Mycobacterium tuberculosis strain Beijing-like/50148

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag BJM03_RS18510 Protein ID WP_003417760.1
Coordinates 3801254..3801511 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag BJM03_RS18505 Protein ID WP_003417757.1
Coordinates 3800982..3801257 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM03_RS22150 3797780..3799217 - 1438 Protein_3492 FAD-binding oxidoreductase -
BJM03_RS18490 3799320..3799709 + 390 WP_003417745.1 DUF732 domain-containing protein -
BJM03_RS18495 3799723..3800016 - 294 WP_003417749.1 DUF3017 domain-containing protein -
BJM03_RS18500 3800013..3800858 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
BJM03_RS18505 3800982..3801257 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
BJM03_RS18510 3801254..3801511 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
BJM03_RS18515 3801553..3802743 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
BJM03_RS18520 3802860..3803228 + 369 WP_003417765.1 FHA domain-containing protein -
BJM03_RS18525 3803225..3803776 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
BJM03_RS18530 3803783..3804364 - 582 WP_003417769.1 ATP/GTP-binding protein -
BJM03_RS18535 3804345..3804713 - 369 WP_003417772.1 DUF742 domain-containing protein -
BJM03_RS18540 3804691..3805083 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T67735 WP_003417760.1 NZ_CP017597:3801254-3801511 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T67735 NZ_CP017597:3801254-3801511 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT67735 WP_003417757.1 NZ_CP017597:3800982-3801257 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT67735 NZ_CP017597:3800982-3801257 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References