Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3730398..3731072 Replicon chromosome
Accession NZ_CP017597
Organism Mycobacterium tuberculosis strain Beijing-like/50148

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BJM03_RS18275 Protein ID WP_003417282.1
Coordinates 3730398..3730826 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BJM03_RS18280 Protein ID WP_003417286.1
Coordinates 3730830..3731072 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM03_RS18250 3726220..3726621 - 402 WP_003417264.1 cytidine deaminase -
BJM03_RS18255 3726762..3727196 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
BJM03_RS18260 3727193..3727627 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
BJM03_RS18265 3727756..3729528 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
BJM03_RS18270 3729528..3730319 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
BJM03_RS18275 3730398..3730826 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
BJM03_RS18280 3730830..3731072 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
BJM03_RS18285 3731194..3731808 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
BJM03_RS18290 3731805..3732470 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
BJM03_RS18295 3732471..3733004 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
BJM03_RS18300 3733001..3733375 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
BJM03_RS18305 3733472..3734536 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T67734 WP_003417282.1 NZ_CP017597:c3730826-3730398 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T67734 NZ_CP017597:c3730826-3730398 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT67734 WP_003417286.1 NZ_CP017597:c3731072-3730830 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT67734 NZ_CP017597:c3731072-3730830 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References