Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3135236..3135806 | Replicon | chromosome |
Accession | NZ_CP017597 | ||
Organism | Mycobacterium tuberculosis strain Beijing-like/50148 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | BJM03_RS15440 | Protein ID | WP_003414166.1 |
Coordinates | 3135236..3135592 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | BJM03_RS15445 | Protein ID | WP_003901465.1 |
Coordinates | 3135576..3135806 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BJM03_RS15420 | 3130688..3132376 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
BJM03_RS15425 | 3132380..3132706 | - | 327 | WP_003414157.1 | hypothetical protein | - |
BJM03_RS15430 | 3132879..3133466 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
BJM03_RS15435 | 3133485..3135134 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
BJM03_RS15440 | 3135236..3135592 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
BJM03_RS15445 | 3135576..3135806 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
BJM03_RS15450 | 3135849..3136892 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
BJM03_RS21745 | 3137083..3137358 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
BJM03_RS21750 | 3137534..3137788 | - | 255 | WP_003917684.1 | hypothetical protein | - |
BJM03_RS15465 | 3137936..3138340 | + | 405 | WP_003414181.1 | hypothetical protein | - |
BJM03_RS15470 | 3138337..3138528 | + | 192 | WP_003414184.1 | hypothetical protein | - |
BJM03_RS15475 | 3138592..3139881 | + | 1290 | Protein_2925 | transposase family protein | - |
BJM03_RS15480 | 3140115..3140372 | + | 258 | WP_003899489.1 | hypothetical protein | - |
BJM03_RS15485 | 3140477..3140788 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T67728 WP_003414166.1 NZ_CP017597:c3135592-3135236 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T67728 NZ_CP017597:c3135592-3135236 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT67728 WP_003901465.1 NZ_CP017597:c3135806-3135576 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT67728 NZ_CP017597:c3135806-3135576 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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