Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2880555..2881195 Replicon chromosome
Accession NZ_CP017597
Organism Mycobacterium tuberculosis strain Beijing-like/50148

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag BJM03_RS13985 Protein ID WP_003412970.1
Coordinates 2880555..2880974 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag BJM03_RS13990 Protein ID WP_003412975.1
Coordinates 2880971..2881195 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM03_RS13955 2876145..2876867 - 723 WP_003412957.1 DUF1906 domain-containing protein -
BJM03_RS13965 2877384..2877606 + 223 Protein_2635 type II toxin-antitoxin system VapB family antitoxin -
BJM03_RS13970 2877603..2878004 + 402 WP_003412963.1 PIN domain-containing protein -
BJM03_RS13975 2878039..2878959 - 921 WP_003412965.1 restriction endonuclease -
BJM03_RS22100 2879300..2879545 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BJM03_RS13980 2879604..2880554 + 951 WP_003911916.1 Lsr2 family protein -
BJM03_RS13985 2880555..2880974 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
BJM03_RS13990 2880971..2881195 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
BJM03_RS13995 2881226..2884069 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
BJM03_RS14000 2884141..2884542 - 402 WP_003412981.1 hypothetical protein -
BJM03_RS14005 2884542..2885012 - 471 WP_003899364.1 transcription antitermination factor NusB -
BJM03_RS14010 2885015..2885578 - 564 WP_003412989.1 elongation factor P -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-128)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T67720 WP_003412970.1 NZ_CP017597:c2880974-2880555 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T67720 NZ_CP017597:c2880974-2880555 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT67720 WP_003412975.1 NZ_CP017597:c2881195-2880971 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT67720 NZ_CP017597:c2881195-2880971 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ08


Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References