Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2431810..2432339 Replicon chromosome
Accession NZ_CP017597
Organism Mycobacterium tuberculosis strain Beijing-like/50148

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag BJM03_RS11785 Protein ID WP_003411124.1
Coordinates 2431810..2432127 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag BJM03_RS11790 Protein ID WP_003411127.1
Coordinates 2432124..2432339 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM03_RS11755 2426947..2428023 + 1077 WP_003411110.1 hypothetical protein -
BJM03_RS11760 2428020..2428301 + 282 WP_003411112.1 hypothetical protein -
BJM03_RS11765 2428337..2429410 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
BJM03_RS11770 2429415..2429945 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
BJM03_RS11775 2429993..2431339 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
BJM03_RS11785 2431810..2432127 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BJM03_RS11790 2432124..2432339 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
BJM03_RS11795 2432594..2433652 + 1059 WP_003411129.1 hypothetical protein -
BJM03_RS11800 2433782..2434138 - 357 WP_003411130.1 hypothetical protein -
BJM03_RS11805 2434233..2435015 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
BJM03_RS11810 2435283..2435573 - 291 WP_003900476.1 YggT family protein -
BJM03_RS11815 2435735..2436391 - 657 WP_003411133.1 cell division protein SepF -
BJM03_RS11820 2436453..2437232 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T67718 WP_003411124.1 NZ_CP017597:c2432127-2431810 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T67718 NZ_CP017597:c2432127-2431810 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT67718 WP_003411127.1 NZ_CP017597:c2432339-2432124 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT67718 NZ_CP017597:c2432339-2432124 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References