Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3771172..3771701 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag BJM02_RS18395 Protein ID WP_003417760.1
Coordinates 3771444..3771701 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag BJM02_RS18390 Protein ID WP_003417757.1
Coordinates 3771172..3771447 (+) Length 92 a.a.

Genomic Context

BJM02_RS18375BJM02_RS18390BJM02_RS18395BJM02_RS18400BJM02_RS18405BJM02_RS22090BJM02_RS18380BJM02_RS18385BJM02_RS18410BJM02_RS18415BJM02_RS18420BJM02_RS18425
Location: 3769510..3769899 (390 bp)
Type: Others
Protein ID: WP_003417745.1
Location: 3771172..3771447 (276 bp)
Type: Antitoxin
Protein ID: WP_003417757.1
Location: 3771444..3771701 (258 bp)
Type: Toxin
Protein ID: WP_003417760.1
Location: 3771743..3772933 (1191 bp)
Type: Others
Protein ID: WP_003900033.1
Location: 3773050..3773418 (369 bp)
Type: Others
Protein ID: WP_003417765.1
Location: 3767970..3769407 (1438 bp)
Type: Others
Protein ID: Protein_3469
Location: 3769913..3770206 (294 bp)
Type: Others
Protein ID: WP_003417749.1
Location: 3770203..3771048 (846 bp)
Type: Others
Protein ID: WP_003417751.1
Location: 3773415..3773966 (552 bp)
Type: Others
Protein ID: WP_003417767.1
Location: 3773973..3774554 (582 bp)
Type: Others
Protein ID: WP_003417769.1
Location: 3774535..3774903 (369 bp)
Type: Others
Protein ID: WP_003417772.1
Location: 3774881..3775273 (393 bp)
Type: Others
Protein ID: WP_003417776.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJM02_RS220903767970..3769407-1438Protein_3469FAD-binding oxidoreductase-
BJM02_RS183753769510..3769899+390WP_003417745.1DUF732 domain-containing protein-
BJM02_RS183803769913..3770206-294WP_003417749.1DUF3017 domain-containing protein-
BJM02_RS183853770203..3771048-846WP_003417751.1bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase-
BJM02_RS183903771172..3771447+276WP_003417757.1type II toxin-antitoxin system antitoxin RelJAntitoxin
BJM02_RS183953771444..3771701+258WP_003417760.1Txe/YoeB family addiction module toxinToxin
BJM02_RS184003771743..3772933+1191WP_003900033.1NADH:flavin oxidoreductase-
BJM02_RS184053773050..3773418+369WP_003417765.1FHA domain-containing protein-
BJM02_RS184103773415..3773966-552WP_003417767.1pentapeptide repeat protein MfpA-
BJM02_RS184153773973..3774554-582WP_003417769.1ATP/GTP-binding protein-
BJM02_RS184203774535..3774903-369WP_003417772.1DUF742 domain-containing protein-
BJM02_RS184253774881..3775273-393WP_003417776.1roadblock/LC7 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T67675 WP_003417760.1 NZ_CP017596:3771444-3771701 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T67675 NZ_CP017596:3771444-3771701 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT67675 WP_003417757.1 NZ_CP017596:3771172-3771447 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT67675 NZ_CP017596:3771172-3771447 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB3OEI

Antitoxin

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Source
ID
Structure
PDB3CTO
PDB3OEI
PDB3D55
AlphaFold DBG0TI94

References