Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3700584..3701258 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BJM02_RS18135 Protein ID WP_003417282.1
Coordinates 3700584..3701012 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BJM02_RS18140 Protein ID WP_003417286.1
Coordinates 3701016..3701258 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM02_RS18110 3696406..3696807 - 402 WP_003417264.1 cytidine deaminase -
BJM02_RS18115 3696948..3697382 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
BJM02_RS18120 3697379..3697813 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
BJM02_RS18125 3697942..3699714 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
BJM02_RS18130 3699714..3700505 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
BJM02_RS18135 3700584..3701012 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
BJM02_RS18140 3701016..3701258 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
BJM02_RS18145 3701380..3701994 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
BJM02_RS18150 3701991..3702656 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
BJM02_RS18155 3702657..3703190 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
BJM02_RS18160 3703187..3703561 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
BJM02_RS18165 3703658..3704722 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T67674 WP_003417282.1 NZ_CP017596:c3701012-3700584 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T67674 NZ_CP017596:c3701012-3700584 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT67674 WP_003417286.1 NZ_CP017596:c3701258-3701016 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT67674 NZ_CP017596:c3701258-3701016 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References