Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3700584..3701258 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BJM02_RS18135 Protein ID WP_003417282.1
Coordinates 3700584..3701012 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BJM02_RS18140 Protein ID WP_003417286.1
Coordinates 3701016..3701258 (-) Length 81 a.a.

Genomic Context

BJM02_RS18115BJM02_RS18120BJM02_RS18125BJM02_RS18130BJM02_RS18110BJM02_RS18135BJM02_RS18140BJM02_RS18145BJM02_RS18150BJM02_RS18155BJM02_RS18160BJM02_RS18165
Location: 3696948..3697382 (435 bp)
Type: Others
Protein ID: WP_003900017.1
Location: 3697379..3697813 (435 bp)
Type: Others
Protein ID: WP_003902441.1
Location: 3697942..3699714 (1773 bp)
Type: Others
Protein ID: WP_003417273.1
Location: 3699714..3700505 (792 bp)
Type: Others
Protein ID: WP_003417279.1
Location: 3696406..3696807 (402 bp)
Type: Others
Protein ID: WP_003417264.1
Location: 3700584..3701012 (429 bp)
Type: Toxin
Protein ID: WP_003417282.1
Location: 3701016..3701258 (243 bp)
Type: Antitoxin
Protein ID: WP_003417286.1
Location: 3701380..3701994 (615 bp)
Type: Others
Protein ID: WP_003417288.1
Location: 3701991..3702656 (666 bp)
Type: Others
Protein ID: WP_003417290.1
Location: 3702657..3703190 (534 bp)
Type: Others
Protein ID: WP_003417293.1
Location: 3703187..3703561 (375 bp)
Type: Others
Protein ID: WP_003417295.1
Location: 3703658..3704722 (1065 bp)
Type: Others
Protein ID: WP_003913037.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJM02_RS181103696406..3696807-402WP_003417264.1cytidine deaminase-
BJM02_RS181153696948..3697382+435WP_003900017.1succinate dehydrogenase, cytochrome b556 subunit-
BJM02_RS181203697379..3697813+435WP_003902441.1succinate dehydrogenase hydrophobic membrane anchor subunit-
BJM02_RS181253697942..3699714+1773WP_003417273.1succinate dehydrogenase flavoprotein subunit-
BJM02_RS181303699714..3700505+792WP_003417279.1succinate dehydrogenase iron-sulfur subunit-
BJM02_RS181353700584..3701012-429WP_003417282.1type II toxin-antitoxin system VapC family toxinToxin
BJM02_RS181403701016..3701258-243WP_003417286.1ribbon-helix-helix domain-containing proteinAntitoxin
BJM02_RS181453701380..3701994-615WP_003417288.1class I SAM-dependent methyltransferase-
BJM02_RS181503701991..3702656-666WP_003417290.1molybdopterin converting factor subunit 1-
BJM02_RS181553702657..3703190-534WP_003417293.1cyclic pyranopterin monophosphate synthase MoaC-
BJM02_RS181603703187..3703561-375WP_003417295.14a-hydroxytetrahydrobiopterin dehydratase-
BJM02_RS181653703658..3704722-1065WP_003913037.1GTP 3',8-cyclase MoaA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T67674 WP_003417282.1 NZ_CP017596:c3701012-3700584 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T67674 NZ_CP017596:c3701012-3700584 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT67674 WP_003417286.1 NZ_CP017596:c3701258-3701016 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT67674 NZ_CP017596:c3701258-3701016 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4FBL0

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TI59

References