Detailed information of TA system TA067657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2360548..2361243
• Replicon: chromosome
• Accession: NZ_CP017596
• Organism: Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BJM02_RS11415
• Protein ID: WP_003905754.1
• Coordinates: 2360548..2360982 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: BJM02_RS11420
• Protein ID: WP_003410814.1
• Coordinates: 2360989..2361243 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJM02_RS11405	2356700..2359743	+	3044	Protein_2162	DEAD/DEAH box helicase	-
BJM02_RS11410	2359736..2360569	+	834	WP_003899172.1	SWIM zinc finger family protein	-
BJM02_RS11415	2360548..2360982	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
BJM02_RS11420	2360989..2361243	-	255	WP_003410814.1	antitoxin	Antitoxin
BJM02_RS11425	2361259..2361516	-	258	WP_003410816.1	hypothetical protein	-
BJM02_RS11435	2362050..2363311	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
BJM02_RS11440	2363821..2364117	+	297	WP_003410820.1	PE family protein	-
BJM02_RS11445	2364173..2364904	+	732	WP_003900467.1	PPE family protein	-
BJM02_RS11450	2365444..2366190	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T67657 WP_003905754.1 NZ_CP017596:c2360982-2360548 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T67657 NZ_CP017596:c2360982-2360548 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT67657 WP_003410814.1 NZ_CP017596:c2361243-2360989 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT67657 NZ_CP017596:c2361243-2360989 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0