Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2180286..2180989 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag BJM02_RS10455 Protein ID WP_003409778.1
Coordinates 2180286..2180615 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag BJM02_RS10460 Protein ID WP_003409780.1
Coordinates 2180612..2180989 (-) Length 126 a.a.

Genomic Context

BJM02_RS10435BJM02_RS10440BJM02_RS10445BJM02_RS10450BJM02_RS10470BJM02_RS10480BJM02_RS10455BJM02_RS10460BJM02_RS10465BJM02_RS10475BJM02_RS10485BJM02_RS10490BJM02_RS10495BJM02_RS10500
Location: 2176669..2177739 (1071 bp)
Type: Others
Protein ID: WP_003902252.1
Location: 2177736..2178251 (516 bp)
Type: Others
Protein ID: WP_003409718.1
Location: 2178248..2179309 (1062 bp)
Type: Others
Protein ID: WP_003899092.1
Location: 2179306..2180076 (771 bp)
Type: Others
Protein ID: WP_003409775.1
Location: 2181631..2182995 (1365 bp)
Type: Others
Protein ID: WP_003903691.1
Location: 2183666..2184067 (402 bp)
Type: Others
Protein ID: WP_003409869.1
Location: 2180286..2180615 (330 bp)
Type: Toxin
Protein ID: WP_003409778.1
Location: 2180612..2180989 (378 bp)
Type: Antitoxin
Protein ID: WP_003409780.1
Location: 2180986..2181576 (591 bp)
Type: Others
Protein ID: WP_003409784.1
Location: 2183150..2183602 (453 bp)
Type: Others
Protein ID: WP_003899095.1
Location: 2184060..2184242 (183 bp)
Type: Others
Protein ID: WP_003409870.1
Location: 2184356..2184706 (351 bp)
Type: Others
Protein ID: WP_003409871.1
Location: 2184717..2185619 (903 bp)
Type: Others
Protein ID: WP_003899097.1
Location: 2185640..2185831 (192 bp)
Type: Others
Protein ID: WP_003409876.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJM02_RS104352176669..2177739+1071WP_003902252.1epoxide hydrolase EphB-
BJM02_RS104402177736..2178251+516WP_003409718.1flavin reductase family protein-
BJM02_RS104452178248..2179309+1062WP_003899092.13,4-dihydroxy-2-butanone-4-phosphate synthase-
BJM02_RS104502179306..2180076+771WP_003409775.1SDR family oxidoreductase-
BJM02_RS104552180286..2180615-330WP_003409778.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BJM02_RS104602180612..2180989-378WP_003409780.1type II toxin-antitoxin system antitoxin MazE5Antitoxin
BJM02_RS104652180986..2181576-591WP_003409784.1SEC-C domain-containing protein-
BJM02_RS104702181631..2182995+1365WP_003903691.1HNH endonuclease-
BJM02_RS104752183150..2183602-453WP_003899095.1lipoprotein-
BJM02_RS104802183666..2184067+402WP_003409869.1hypothetical protein-
BJM02_RS104852184060..2184242-183WP_003409870.1hypothetical protein-
BJM02_RS104902184356..2184706-351WP_003409871.1hypothetical protein-
BJM02_RS104952184717..2185619-903WP_003899097.1hypothetical protein-
BJM02_RS105002185640..2185831-192WP_003409876.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T67648 WP_003409778.1 NZ_CP017596:c2180615-2180286 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

>T67648 NZ_CP017596:c2180615-2180286 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT67648 WP_003409780.1 NZ_CP017596:c2180989-2180612 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp

>AT67648 NZ_CP017596:c2180989-2180612 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TLK7

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TLK8

References