Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1940217..1940830 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag BJM02_RS09300 Protein ID WP_003408465.1
Coordinates 1940217..1940606 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag BJM02_RS09305 Protein ID WP_003408469.1
Coordinates 1940603..1940830 (-) Length 76 a.a.

Genomic Context

BJM02_RS09270BJM02_RS09275BJM02_RS09280BJM02_RS09285BJM02_RS09290BJM02_RS09310BJM02_RS09315BJM02_RS09300BJM02_RS09305BJM02_RS09320BJM02_RS09325
Location: 1935846..1936760 (915 bp)
Type: Others
Protein ID: WP_003898985.1
Location: 1936763..1937593 (831 bp)
Type: Others
Protein ID: WP_003408448.1
Location: 1937593..1937943 (351 bp)
Type: Others
Protein ID: WP_003898986.1
Location: 1937996..1938814 (819 bp)
Type: Others
Protein ID: WP_003408456.1
Location: 1938828..1939607 (780 bp)
Type: Others
Protein ID: WP_003408460.1
Location: 1941048..1942532 (1485 bp)
Type: Others
Protein ID: WP_003408473.1
Location: 1942529..1943776 (1248 bp)
Type: Others
Protein ID: WP_003408476.1
Location: 1940217..1940606 (390 bp)
Type: Toxin
Protein ID: WP_003408465.1
Location: 1940603..1940830 (228 bp)
Type: Antitoxin
Protein ID: WP_003408469.1
Location: 1943819..1944238 (420 bp)
Type: Others
Protein ID: WP_003408483.1
Location: 1944228..1944938 (711 bp)
Type: Others
Protein ID: WP_003408486.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJM02_RS092701935846..1936760+915WP_003898985.13-hydroxyacyl-CoA dehydrogenase family protein-
BJM02_RS092751936763..1937593+831WP_003408448.1cyclase family protein-
BJM02_RS092801937593..1937943+351WP_003898986.1cupin domain-containing protein-
BJM02_RS092851937996..1938814+819WP_003408456.13-keto-5-aminohexanoate cleavage protein-
BJM02_RS092901938828..1939607+780WP_003408460.1IclR family transcriptional regulator-
BJM02_RS093001940217..1940606-390WP_003408465.1PIN domain-containing proteinToxin
BJM02_RS093051940603..1940830-228WP_003408469.1antitoxinAntitoxin
BJM02_RS093101941048..1942532+1485WP_003408473.1carboxylase-
BJM02_RS093151942529..1943776+1248WP_003408476.1serine hydrolase-
BJM02_RS093201943819..1944238-420WP_003408483.1hypothetical protein-
BJM02_RS093251944228..1944938-711WP_003408486.1winged helix-turn-helix transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T67646 WP_003408465.1 NZ_CP017596:c1940606-1940217 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T67646 NZ_CP017596:c1940606-1940217 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT67646 WP_003408469.1 NZ_CP017596:c1940830-1940603 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT67646 NZ_CP017596:c1940830-1940603 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4BUI9

Antitoxin

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Source
ID
Structure
PDB7E4J
AlphaFold DBA0A7U4FAN9

References