Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 693010..693656 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag BJM02_RS03160 Protein ID WP_003403122.1
Coordinates 693010..693402 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag BJM02_RS03165 Protein ID WP_003403125.1
Coordinates 693399..693656 (-) Length 86 a.a.

Genomic Context

BJM02_RS03145BJM02_RS03150BJM02_RS03155BJM02_RS03200BJM02_RS03160BJM02_RS03165BJM02_RS03170BJM02_RS03175BJM02_RS03180BJM02_RS03185BJM02_RS03190BJM02_RS03195
Location: 688672..690198 (1527 bp)
Type: Others
Protein ID: WP_003403112.1
Location: 690261..691403 (1143 bp)
Type: Others
Protein ID: WP_003911253.1
Location: 691408..692958 (1551 bp)
Type: Others
Protein ID: WP_003905349.1
Location: 698027..698338 (312 bp)
Type: Others
Protein ID: WP_003403164.1
Location: 693010..693402 (393 bp)
Type: Toxin
Protein ID: WP_003403122.1
Location: 693399..693656 (258 bp)
Type: Antitoxin
Protein ID: WP_003403125.1
Location: 693839..695074 (1236 bp)
Type: Others
Protein ID: WP_003403128.1
Location: 695325..695738 (414 bp)
Type: Others
Protein ID: WP_003403137.1
Location: 695735..695971 (237 bp)
Type: Others
Protein ID: WP_003403139.1
Location: 696075..696581 (507 bp)
Type: Others
Protein ID: WP_003900973.1
Location: 696695..697225 (531 bp)
Type: Others
Protein ID: WP_003917320.1
Location: 697209..697904 (696 bp)
Type: Others
Protein ID: WP_003918099.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJM02_RS03145688672..690198+1527WP_003403112.1virulence factor Mce family protein-
BJM02_RS03150690261..691403+1143WP_003911253.1virulence factor Mce family protein-
BJM02_RS03155691408..692958+1551WP_003905349.1MCE family protein-
BJM02_RS03160693010..693402-393WP_003403122.1type II toxin-antitoxin system toxin ribonuclease C4Toxin
BJM02_RS03165693399..693656-258WP_003403125.1type II toxin-antitoxin system antitoxin VapB4Antitoxin
BJM02_RS03170693839..695074-1236WP_003403128.1ATP-binding protein-
BJM02_RS03175695325..695738-414WP_003403137.1type II toxin-antitoxin system VapC family toxin-
BJM02_RS03180695735..695971-237WP_003403139.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
BJM02_RS03185696075..696581-507WP_003900973.1two component system sensor kinase HK1-
BJM02_RS03190696695..697225-531WP_003917320.1two component system sensor kinase HK2-
BJM02_RS03195697209..697904-696WP_003918099.1two-component system response regulator TcrA-
BJM02_RS03200698027..698338+312WP_003403164.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T67625 WP_003403122.1 NZ_CP017596:c693402-693010 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T67625 NZ_CP017596:c693402-693010 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT67625 WP_003403125.1 NZ_CP017596:c693656-693399 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT67625 NZ_CP017596:c693656-693399 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4F8V4

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TQ86

References