67608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3120734..3121304 Replicon chromosome
Accession NZ_CP017595
Organism Mycobacterium tuberculosis strain Beijing-like/38774

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag BJM01_RS15405 Protein ID WP_003414166.1
Coordinates 3120734..3121090 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag BJM01_RS15410 Protein ID WP_003901465.1
Coordinates 3121074..3121304 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM01_RS15385 3116186..3117874 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
BJM01_RS15390 3117878..3118204 - 327 WP_003414157.1 hypothetical protein -
BJM01_RS15395 3118377..3118964 + 588 WP_003914429.1 DUF3558 family protein -
BJM01_RS15400 3118983..3120632 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
BJM01_RS15405 3120734..3121090 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
BJM01_RS15410 3121074..3121304 - 231 WP_003901465.1 antitoxin MazE Antitoxin
BJM01_RS15415 3121347..3122390 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
BJM01_RS21725 3122581..3122856 + 276 WP_003911993.1 DUF1778 domain-containing protein -
BJM01_RS21730 3123032..3123286 - 255 WP_003917684.1 hypothetical protein -
BJM01_RS15430 3123434..3123838 + 405 WP_003414181.1 hypothetical protein -
BJM01_RS15435 3123835..3124026 + 192 WP_003414184.1 hypothetical protein -
BJM01_RS15440 3124090..3125379 + 1290 Protein_2916 transposase family protein -
BJM01_RS15445 3125613..3125870 + 258 WP_003899489.1 hypothetical protein -
BJM01_RS15450 3125975..3126286 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-113)

Antitoxin

(3-29)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T67608 WP_003414166.1 NZ_CP017595:c3121090-3120734 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T67608 NZ_CP017595:c3121090-3120734 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT67608 WP_003901465.1 NZ_CP017595:c3121304-3121074 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT67608 NZ_CP017595:c3121304-3121074 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References