67604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2941855..2942569 Replicon chromosome
Accession NZ_CP017595
Organism Mycobacterium tuberculosis strain Beijing-like/38774

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag BJM01_RS14345 Protein ID WP_003413460.1
Coordinates 2942129..2942569 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag BJM01_RS14340 Protein ID WP_003413456.1
Coordinates 2941855..2942142 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM01_RS14305 2937277..2937522 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BJM01_RS14310 2937519..2937923 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
BJM01_RS14315 2938140..2938760 + 621 WP_003413441.1 DUF4178 domain-containing protein -
BJM01_RS14320 2938771..2939265 + 495 WP_003413444.1 DUF2617 family protein -
BJM01_RS14325 2939262..2939693 + 432 WP_003899390.1 DUF4247 domain-containing protein -
BJM01_RS14330 2939718..2940176 + 459 WP_003413451.1 DUF350 domain-containing protein -
BJM01_RS14335 2940173..2941744 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
BJM01_RS14340 2941855..2942142 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
BJM01_RS14345 2942129..2942569 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
BJM01_RS14350 2942590..2943345 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
BJM01_RS14355 2943478..2944074 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
BJM01_RS14360 2944082..2944927 - 846 WP_003413466.1 acyl-CoA thioesterase II -
BJM01_RS14365 2944956..2945855 - 900 WP_031709355.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
BJM01_RS14370 2945983..2946657 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T67604 WP_003413460.1 NZ_CP017595:2942129-2942569 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T67604 NZ_CP017595:2942129-2942569 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT67604 WP_003413456.1 NZ_CP017595:2941855-2942142 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT67604 NZ_CP017595:2941855-2942142 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References