67525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1796820..1797433 Replicon chromosome
Accession NZ_CP017594
Organism Mycobacterium tuberculosis strain Beijing-like/36918

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag BJM00_RS08685 Protein ID WP_003407786.1
Coordinates 1797029..1797433 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag BJM00_RS08680 Protein ID WP_009935474.1
Coordinates 1796820..1797023 (+) Length 68 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM00_RS08650 1792225..1792605 + 381 WP_003407768.1 fumarate reductase subunit C -
BJM00_RS08655 1792602..1792979 + 378 WP_031651792.1 fumarate reductase subunit FrdD -
BJM00_RS08660 1793047..1793655 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
BJM00_RS08665 1793839..1794987 + 1149 Protein_1640 MMPL family transporter -
BJM00_RS08670 1794997..1795443 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
BJM00_RS08675 1795478..1796767 + 1290 WP_003407781.1 threonine ammonia-lyase -
BJM00_RS08680 1796820..1797023 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BJM00_RS08685 1797029..1797433 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
BJM00_RS08690 1797450..1799192 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
BJM00_RS08695 1799185..1801482 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-124)

Antitoxin

(2-44)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T67525 WP_003407786.1 NZ_CP017594:1797029-1797433 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T67525 NZ_CP017594:1797029-1797433 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT67525 WP_009935474.1 NZ_CP017594:1796820-1797023 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT67525 NZ_CP017594:1796820-1797023 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6A7V


Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References