67503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 644557..645233 Replicon chromosome
Accession NZ_CP017594
Organism Mycobacterium tuberculosis strain Beijing-like/36918

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag BJM00_RS02950 Protein ID WP_003898500.1
Coordinates 644557..644970 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag BJM00_RS02955 Protein ID WP_003402915.1
Coordinates 644967..645233 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM00_RS02920 639902..640204 - 303 WP_003402896.1 DUF3349 domain-containing protein -
BJM00_RS02925 640264..640542 - 279 WP_003402901.1 hypothetical protein -
BJM00_RS02930 640539..641792 - 1254 WP_003402904.1 inorganic phosphate transporter family protein -
BJM00_RS02935 641912..642298 - 387 WP_003402907.1 VOC family protein -
BJM00_RS02940 642361..643245 - 885 WP_003402909.1 SDR family oxidoreductase -
BJM00_RS02945 643341..644243 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
BJM00_RS02950 644557..644970 - 414 WP_003898500.1 PIN domain-containing protein Toxin
BJM00_RS02955 644967..645233 - 267 WP_003402915.1 antitoxin VapB3 Antitoxin
BJM00_RS02960 645425..647140 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
BJM00_RS02965 647218..648822 + 1605 WP_003402920.1 amidohydrolase -
BJM00_RS02970 648819..649799 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T67503 WP_003898500.1 NZ_CP017594:c644970-644557 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T67503 NZ_CP017594:c644970-644557 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT67503 WP_003402915.1 NZ_CP017594:c645233-644967 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT67503 NZ_CP017594:c645233-644967 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References