Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 49116..49636 Replicon plasmid pDSJ10
Accession NZ_CP017591
Organism Pantoea stewartii subsp. stewartii DC283

Toxin (Protein)


Gene name ccdB Uniprot ID H3RK38
Locus tag DSJ_RS25700 Protein ID WP_006121898.1
Coordinates 49116..49415 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H3RK39
Locus tag DSJ_RS25705 Protein ID WP_006121899.1
Coordinates 49418..49636 (-) Length 73 a.a.

Genomic Context

DSJ_RS25680DSJ_RS25685DSJ_RS25690DSJ_RS25695DSJ_RS25710DSJ_RS25700DSJ_RS25705DSJ_RS25715DSJ_RS25720DSJ_RS25725DSJ_RS25730DSJ_RS25735
Location: 44722..45840 (1119 bp)
Type: Others
Protein ID: Protein_44
Location: 45842..46846 (1005 bp)
Type: Others
Protein ID: WP_006121895.1
Location: 46864..48234 (1371 bp)
Type: Others
Protein ID: WP_006121896.1
Location: 48252..48947 (696 bp)
Type: Others
Protein ID: WP_006121897.1
Location: 50149..50409 (261 bp)
Type: Others
Protein ID: WP_006121900.1
Location: 49116..49415 (300 bp)
Type: Toxin
Protein ID: WP_006121898.1
Location: 49418..49636 (219 bp)
Type: Antitoxin
Protein ID: WP_006121899.1
Location: 50612..51037 (426 bp)
Type: Others
Protein ID: WP_006121901.1
Location: 51039..51335 (297 bp)
Type: Others
Protein ID: WP_044243057.1
Location: 51342..52913 (1572 bp)
Type: Others
Protein ID: WP_006117591.1
Location: 52933..53280 (348 bp)
Type: Others
Protein ID: WP_006118527.1
Location: 53277..53906 (630 bp)
Type: Others
Protein ID: WP_044242011.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DSJ_RS2568044722..45840+1119Protein_44glucan 1,4-alpha-glucosidase-
DSJ_RS2568545842..46846+1005WP_006121895.1decarboxylating 6-phosphogluconate dehydrogenase-
DSJ_RS2569046864..48234+1371WP_006121896.1glucose-6-phosphate dehydrogenase-
DSJ_RS2569548252..48947+696WP_006121897.1ROK family protein-
DSJ_RS2570049116..49415-300WP_006121898.1CcdB family proteinToxin
DSJ_RS2570549418..49636-219WP_006121899.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
DSJ_RS2571050149..50409+261WP_006121900.1hypothetical protein-
DSJ_RS2571550612..51037-426WP_006121901.1ATP-binding protein-
DSJ_RS2572051039..51335-297WP_044243057.1STAS domain-containing protein-
DSJ_RS2572551342..52913-1572WP_006117591.1IS66 family transposase-
DSJ_RS2573052933..53280-348WP_006118527.1IS66 family insertion sequence element accessory protein TnpB-
DSJ_RS2573553277..53906-630WP_044242011.1IS66 family insertion sequence hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-fliC1..304641304641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-98)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10974.67 Da        Isoelectric Point: 7.0045

>T67436 WP_006121898.1 NZ_CP017591:c49415-49116 [Pantoea stewartii subsp. stewartii DC283]
MQFDVYSHKNGKKYPYLVEVQSYLIDTPGRLMVAPLALPGEFVGSGELYPEVLVNGSKYRVVTTDIASVPVKALGDKVGD
VSQYEAAIKNAIFRLFWGF

Download         Length: 300 bp

>T67436 NZ_CP017591:c49415-49116 [Pantoea stewartii subsp. stewartii DC283]
ATGCAATTTGACGTTTACTCACACAAGAATGGTAAAAAATATCCTTATCTTGTTGAAGTACAAAGCTACCTGATAGACAC
ACCAGGCCGTTTAATGGTCGCCCCCCTTGCTCTTCCGGGCGAGTTCGTGGGTTCAGGTGAACTTTATCCTGAGGTACTGG
TTAACGGCAGCAAGTACCGCGTTGTGACAACCGACATTGCATCTGTCCCGGTGAAAGCGTTAGGGGACAAAGTGGGTGAT
GTCAGTCAGTATGAAGCAGCAATAAAAAACGCCATTTTCAGGCTTTTTTGGGGTTTCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8516.56 Da        Isoelectric Point: 5.1504

>AT67436 WP_006121899.1 NZ_CP017591:c49636-49418 [Pantoea stewartii subsp. stewartii DC283]
MKYRTNVTIDKEAYEIFSSAGLNLSKMVNELVTTEARRIRAERWKEENRESMKAFSDFVGEEGSLSDMYRNW

Download         Length: 219 bp

>AT67436 NZ_CP017591:c49636-49418 [Pantoea stewartii subsp. stewartii DC283]
ATGAAATACAGAACTAACGTCACCATTGATAAAGAAGCCTACGAGATATTTTCATCTGCGGGCTTAAACCTTTCTAAAAT
GGTTAACGAGCTTGTCACTACTGAGGCTCGCAGAATCCGGGCTGAACGCTGGAAAGAAGAAAACCGTGAAAGCATGAAAG
CCTTCTCTGACTTTGTGGGAGAAGAGGGATCGCTTTCTGATATGTACAGGAACTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH3RK38

Antitoxin

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Source
ID
Structure
AlphaFold DBH3RK39

References