Detailed information of TA system TA067429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3474711..3475345
• Replicon: chromosome
• Accession: NZ_CP017578
• Organism: Sphingomonas melonis TY

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BJP26_RS16190
• Protein ID: WP_020486407.1
• Coordinates: 3475049..3475345 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A175Y4Z1
• Locus tag: BJP26_RS16185
• Protein ID: WP_017977948.1
• Coordinates: 3474711..3474938 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP26_RS16160	3470118..3470468	+	351	WP_020486406.1	hypothetical protein	-
BJP26_RS16165	3470582..3470952	+	371	Protein_3245	MerC domain-containing protein	-
BJP26_RS16170	3470994..3471461	+	468	WP_017977944.1	transcriptional repressor	-
BJP26_RS16175	3471516..3473441	+	1926	WP_017977945.1	1-deoxy-D-xylulose-5-phosphate synthase	-
BJP26_RS20510	3473438..3473587	+	150	WP_017977946.1	hypothetical protein	-
BJP26_RS16180	3473607..3474650	+	1044	WP_017977947.1	helix-turn-helix transcriptional regulator	-
BJP26_RS16185	3474711..3474938	+	228	WP_017977948.1	hypothetical protein	Antitoxin
BJP26_RS16190	3475049..3475345	+	297	WP_020486407.1	PIN domain-containing protein	Toxin
BJP26_RS16195	3475346..3476017	-	672	WP_017977950.1	alpha/beta hydrolase	-
BJP26_RS16200	3476421..3477161	+	741	WP_017977951.1	TlyA family RNA methyltransferase	-
BJP26_RS16205	3477276..3477794	+	519	WP_017977952.1	tryptophan-rich sensory protein	-
BJP26_RS16210	3477829..3478095	+	267	WP_017977953.1	accessory factor UbiK family protein	-
BJP26_RS16215	3478206..3478709	+	504	WP_017977954.1	YbjN domain-containing protein	-
BJP26_RS16220	3478726..3479505	+	780	WP_029720831.1	NAD(P)-binding domain-containing protein	-
BJP26_RS16225	3479541..3480029	-	489	WP_024310470.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-76)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11119.90 Da
• Isoelectric Point: 5.6193

>T67429 WP_020486407.1 NZ_CP017578:3475049-3475345 [Sphingomonas melonis TY]
MNELANVLRKKLKWEWPRIREAIETVTDRCSTLVILDLDLHHLGLRLAERYRLSVYDAMIAAAALTAECDTLYSEDMHDG
LVIDGRVRIVNPFAPVAG

Nucleotide

• Length: 297 bp

>T67429 NZ_CP017578:3475049-3475345 [Sphingomonas melonis TY]
TTGAACGAACTGGCCAACGTTCTACGCAAGAAGCTCAAATGGGAATGGCCCCGGATCCGTGAGGCAATCGAGACGGTCAC
GGATCGGTGTTCCACTTTGGTAATCCTCGATCTCGACCTCCACCACCTCGGCCTGCGCCTCGCCGAACGCTATCGCCTGT
CGGTCTACGATGCGATGATCGCCGCGGCGGCGCTGACGGCGGAGTGCGATACGCTCTATTCCGAGGATATGCACGACGGG
CTCGTCATCGACGGGCGCGTTCGGATCGTGAATCCGTTTGCGCCCGTCGCGGGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8282.31 Da
• Isoelectric Point: 4.5895

>AT67429 WP_017977948.1 NZ_CP017578:3474711-3474938 [Sphingomonas melonis TY]
MKLEKTADGYVVQVPDDVVAALGLHEGDQVKVAKSNVISLEVSDEDRNSAIDRMKALARPLPPDYKFDRDEANAR

Nucleotide

• Length: 228 bp

>AT67429 NZ_CP017578:3474711-3474938 [Sphingomonas melonis TY]
ATGAAGCTCGAGAAGACCGCCGATGGTTATGTGGTGCAGGTGCCCGACGATGTCGTCGCGGCGCTGGGGTTGCATGAGGG
CGACCAGGTAAAGGTCGCCAAATCCAACGTCATCTCCTTGGAGGTGTCTGATGAGGATCGTAATTCGGCGATCGATCGCA
TGAAGGCCCTGGCAAGGCCTTTGCCCCCCGATTACAAATTTGACCGTGACGAAGCCAACGCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A175Y4Z1