Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PrpT-parD/RHH(antitoxin)
Location 185478..186019 Replicon plasmid pl2WSM5005
Accession NZ_CP017565
Organism Paraburkholderia sprentiae WSM5005

Toxin (Protein)


Gene name PrpT Uniprot ID A0A1I9YW50
Locus tag BJG93_RS33775 Protein ID WP_027196622.1
Coordinates 185717..186019 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1I9YW72
Locus tag BJG93_RS33770 Protein ID WP_027196623.1
Coordinates 185478..185720 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG93_RS33750 181962..182543 - 582 Protein_180 ATP-binding protein -
BJG93_RS33755 182540..183551 - 1012 Protein_181 IS21 family transposase -
BJG93_RS33770 185478..185720 + 243 WP_027196623.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BJG93_RS33775 185717..186019 + 303 WP_027196622.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BJG93_RS37250 186078..186414 + 337 Protein_184 hypothetical protein -
BJG93_RS33780 186829..187161 + 333 WP_071336754.1 hypothetical protein -
BJG93_RS37670 187412..187570 + 159 WP_167544181.1 hypothetical protein -
BJG93_RS33790 187713..188168 + 456 WP_027193709.1 DUF2384 domain-containing protein -
BJG93_RS33795 188165..188635 + 471 WP_154677418.1 RES family NAD+ phosphorylase -
BJG93_RS33800 188643..188837 + 195 WP_027196619.1 hypothetical protein -
BJG93_RS33805 189816..190094 + 279 WP_027196618.1 HU family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..438974 438974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11282.75 Da        Isoelectric Point: 6.3234

>T67423 WP_027196622.1 NZ_CP017565:185717-186019 [Paraburkholderia sprentiae WSM5005]
VKGFVLSPAAELDLNDIWDYSLENWGATQADRYIRLIQDTIIGLVQGTQPSRSASHVRAGYRSVLVGAHIVFFKEHDELV
DVIRILHQRMDPSKHVASEN

Download         Length: 303 bp

>T67423 NZ_CP017565:185717-186019 [Paraburkholderia sprentiae WSM5005]
GTGAAGGGTTTCGTCCTCTCGCCGGCCGCGGAGCTCGATCTGAATGATATATGGGACTACTCGCTCGAAAATTGGGGTGC
CACGCAGGCTGATCGGTATATCCGACTGATTCAGGACACCATAATCGGGTTGGTACAGGGCACGCAACCGAGCCGGTCCG
CTTCCCACGTTCGTGCCGGTTATCGAAGTGTGCTGGTCGGTGCGCACATTGTGTTTTTCAAGGAGCACGATGAGCTGGTC
GATGTCATCCGGATACTTCATCAGCGGATGGATCCTTCGAAACATGTGGCGAGTGAGAACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8892.97 Da        Isoelectric Point: 9.8605

>AT67423 WP_027196623.1 NZ_CP017565:185478-185720 [Paraburkholderia sprentiae WSM5005]
MSKNTSVSLGAHFAEFVEDRVRAGRYSTASDVVRAGLRLLEEQEAKLDALRSELEKGERSGASKPFDFDAFLARKRKSTT

Download         Length: 243 bp

>AT67423 NZ_CP017565:185478-185720 [Paraburkholderia sprentiae WSM5005]
ATGAGCAAGAATACGTCTGTTTCCCTTGGGGCACACTTTGCTGAATTCGTCGAGGACCGCGTTCGCGCCGGGCGCTATAG
CACCGCGAGTGACGTGGTGCGGGCTGGTCTACGCTTGCTCGAAGAACAGGAAGCGAAGCTCGATGCGCTGCGTTCAGAAT
TGGAAAAGGGAGAGCGTTCGGGTGCGTCCAAACCATTTGACTTTGACGCCTTCCTCGCTCGCAAACGGAAGTCGACCACG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9YW50

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9YW72

References