Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3009244..3009833 Replicon chromosome
Accession NZ_CP017561
Organism Paraburkholderia sprentiae WSM5005

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9YIZ7
Locus tag BJG93_RS13375 Protein ID WP_027199193.1
Coordinates 3009651..3009833 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9YIZ6
Locus tag BJG93_RS13370 Protein ID WP_027199194.1
Coordinates 3009244..3009654 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJG93_RS13355 3005504..3007525 + 2022 WP_027199197.1 flagellar biosynthesis protein FlhF -
BJG93_RS13360 3007518..3008387 + 870 WP_027199196.1 AAA family ATPase -
BJG93_RS13365 3008418..3009152 + 735 WP_027199195.1 RNA polymerase sigma factor FliA -
BJG93_RS13370 3009244..3009654 - 411 WP_027199194.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BJG93_RS13375 3009651..3009833 - 183 WP_027199193.1 type II toxin-antitoxin system HicA family toxin Toxin
BJG93_RS13380 3010112..3010558 - 447 WP_027199192.1 flagellar protein FlgN -
BJG93_RS13385 3010653..3011012 - 360 WP_027199191.1 flagellar biosynthesis anti-sigma factor FlgM -
BJG93_RS13390 3011190..3012602 - 1413 WP_027199190.1 flagellar basal body P-ring formation protein FlgA -
BJG93_RS13395 3012819..3013316 + 498 WP_027199189.1 flagellar basal body rod protein FlgB -
BJG93_RS13400 3013445..3013870 + 426 WP_027199188.1 flagellar basal body rod protein FlgC -
BJG93_RS13405 3013881..3014603 + 723 WP_027199187.1 flagellar hook assembly protein FlgD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6468.58 Da        Isoelectric Point: 11.4230

>T67420 WP_027199193.1 NZ_CP017561:c3009833-3009651 [Paraburkholderia sprentiae WSM5005]
MNSAEVVKLIQANGWQLVRIAGSHHHFRHAGKPGLVTVPHPKKDLPAGTLNSILKQAGLK

Download         Length: 183 bp

>T67420 NZ_CP017561:c3009833-3009651 [Paraburkholderia sprentiae WSM5005]
ATGAACAGTGCCGAGGTCGTCAAATTGATCCAAGCGAATGGTTGGCAGCTCGTCCGCATAGCGGGCAGTCACCATCATTT
CAGGCACGCGGGAAAGCCAGGCCTCGTGACTGTCCCGCACCCCAAAAAAGATTTGCCGGCCGGCACCCTGAACAGCATTC
TGAAACAGGCGGGGCTCAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14793.83 Da        Isoelectric Point: 4.6098

>AT67420 WP_027199194.1 NZ_CP017561:c3009654-3009244 [Paraburkholderia sprentiae WSM5005]
MKHLIFPIAIEPGDNTHAFGVVVPDIPGCYSAGDTLEQAYVNAKEAIESHLDTLLDEGLPLPEPLTLGEHRRNPEFAGFT
WGFVTTRNIPALKKAVRINISLPEALVQEIDAYAQAHGMSRSAFLALAAEREMADA

Download         Length: 411 bp

>AT67420 NZ_CP017561:c3009654-3009244 [Paraburkholderia sprentiae WSM5005]
ATGAAGCATCTGATCTTTCCGATCGCCATCGAACCCGGAGACAACACGCACGCGTTCGGCGTCGTGGTACCCGATATTCC
GGGCTGTTACTCCGCGGGCGACACGCTGGAACAAGCGTATGTGAACGCGAAAGAGGCGATCGAATCGCATCTCGACACTT
TGCTCGACGAAGGACTGCCCTTGCCCGAACCGCTCACGCTCGGCGAGCATCGGCGCAATCCCGAGTTCGCTGGGTTCACA
TGGGGTTTCGTGACGACGCGCAATATTCCGGCGTTGAAGAAGGCGGTTCGCATCAACATTTCGCTGCCCGAGGCGCTGGT
GCAGGAGATCGACGCCTATGCGCAGGCGCACGGTATGTCGCGCTCGGCTTTTCTGGCGCTCGCCGCCGAGCGCGAGATGG
CAGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9YIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9YIZ6

References