Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 590599..591217 Replicon chromosome
Accession NZ_CP017560
Organism Sporosarcina ureilytica strain LMG 22257

Toxin (Protein)


Gene name pemK Uniprot ID A0A380CGL8
Locus tag BI350_RS02995 Protein ID WP_075526783.1
Coordinates 590867..591217 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag BI350_RS02990 Protein ID WP_075529208.1
Coordinates 590599..590862 (+) Length 88 a.a.

Genomic Context

BI350_RS02975BI350_RS02980BI350_RS02985BI350_RS02990BI350_RS02995BI350_RS03000BI350_RS03005BI350_RS03010BI350_RS03015BI350_RS03020BI350_RS03025BI350_RS03030BI350_RS02970
Location: 587678..588031 (354 bp)
Type: Others
Protein ID: WP_075526780.1
Location: 588090..589172 (1083 bp)
Type: Others
Protein ID: WP_075526781.1
Location: 589309..590436 (1128 bp)
Type: Others
Protein ID: WP_075526782.1
Location: 590599..590862 (264 bp)
Type: Antitoxin
Protein ID: WP_075529208.1
Location: 590867..591217 (351 bp)
Type: Toxin
Protein ID: WP_075526783.1
Location: 591367..592197 (831 bp)
Type: Others
Protein ID: WP_075526784.1
Location: 592194..592556 (363 bp)
Type: Others
Protein ID: WP_075526785.1
Location: 592559..592963 (405 bp)
Type: Others
Protein ID: WP_075526786.1
Location: 592979..593986 (1008 bp)
Type: Others
Protein ID: WP_075526787.1
Location: 594180..594521 (342 bp)
Type: Others
Protein ID: WP_075529209.1
Location: 594508..594975 (468 bp)
Type: Others
Protein ID: WP_075526788.1
Location: 594953..595741 (789 bp)
Type: Others
Protein ID: WP_075526789.1
Location: 586997..587611 (615 bp)
Type: Others
Protein ID: WP_075526779.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BI350_RS02970586997..587611-615WP_075526779.1rhomboid family intramembrane serine protease-
BI350_RS02975587678..588031+354WP_075526780.1holo-ACP synthase-
BI350_RS02980588090..589172+1083WP_075526781.1outer membrane lipoprotein carrier protein LolA-
BI350_RS02985589309..590436+1128WP_075526782.1alanine racemase-
BI350_RS02990590599..590862+264WP_075529208.1transcriptional regulatorAntitoxin
BI350_RS02995590867..591217+351WP_075526783.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BI350_RS03000591367..592197+831WP_075526784.1STAS domain-containing protein-
BI350_RS03005592194..592556+363WP_075526785.1STAS domain-containing protein-
BI350_RS03010592559..592963+405WP_075526786.1anti-sigma regulatory factor-
BI350_RS03015592979..593986+1008WP_075526787.1PP2C family protein-serine/threonine phosphatase-
BI350_RS03020594180..594521+342WP_075529209.1STAS domain-containing protein-
BI350_RS03025594508..594975+468WP_075526788.1anti-sigma B factor RsbW-
BI350_RS03030594953..595741+789WP_075526789.1RNA polymerase sigma factor SigB-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12985.01 Da        Isoelectric Point: 4.9105

>T67419 WP_075526783.1 NZ_CP017560:590867-591217 [Sporosarcina ureilytica]
MAIKRGDVFFADLSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAEKYQFERDSVILLEQV
RTIDKSRLTDKITHLDEMLMEKVDEALEVSFGLVKF

Download         Length: 351 bp

>T67419 NZ_CP017560:590867-591217 [Sporosarcina ureilytica]
TTGGCAATAAAACGAGGAGACGTCTTTTTTGCAGATCTGTCACCGGTCGTTGGTTCTGAGCAAGGGGGTACAAGACCGGT
CCTTGTCATACAAAATGACATTGGGAACCGGTTTAGTCCAACTGTAATTATCGCAGCAATTACTGCGCAGATTCAGAAAG
CAAAGTTGCCGACACATGTAGAAATCGATGCGGAAAAGTACCAATTCGAGCGGGATTCTGTAATCCTGCTCGAGCAAGTC
CGCACGATTGACAAGTCGAGGTTAACTGATAAAATCACGCATCTTGATGAAATGTTGATGGAAAAAGTCGACGAAGCATT
AGAAGTAAGTTTTGGGCTCGTAAAATTTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10150.59 Da        Isoelectric Point: 6.4876

>AT67419 WP_075529208.1 NZ_CP017560:590599-590862 [Sporosarcina ureilytica]
MREVIVKIPKRMLNENEHTVVHHGQERGDFVYISTKRYETNHEPEAIREAMMKGYVEMSQINLKIATECLHVEFEAQHTV
ERLVSGG

Download         Length: 264 bp

>AT67419 NZ_CP017560:590599-590862 [Sporosarcina ureilytica]
ATGAGAGAGGTTATTGTTAAAATTCCGAAACGAATGTTGAATGAAAATGAACATACGGTCGTCCACCACGGGCAGGAGCG
AGGGGATTTTGTATATATTTCGACAAAACGCTATGAGACCAATCATGAACCTGAGGCAATTCGAGAGGCCATGATGAAAG
GGTATGTTGAAATGTCGCAAATTAACTTGAAAATTGCCACTGAATGTTTACATGTGGAATTTGAAGCTCAGCACACAGTG
GAACGTCTCGTTAGCGGAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A380CGL8

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References