Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1867351..1867890 Replicon chromosome
Accession NZ_CP017552
Organism Mannheimia haemolytica strain 1282

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG607_RS09690 Protein ID WP_006247804.1
Coordinates 1867621..1867890 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG607_RS09685 Protein ID WP_006247803.1
Coordinates 1867351..1867617 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG607_RS09630 1862751..1863386 - 636 Protein_1872 transposase -
BG607_RS09640 1863487..1864197 - 711 Protein_1873 tyrosine-type recombinase/integrase -
BG607_RS09645 1864101..1864424 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG607_RS09650 1864505..1864672 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG607_RS09655 1864680..1865054 - 375 WP_006247798.1 hypothetical protein -
BG607_RS09660 1865204..1865431 + 228 Protein_1877 phage terminase large subunit family protein -
BG607_RS09665 1865456..1865851 + 396 WP_006247799.1 phage tail protein -
BG607_RS09670 1865883..1866524 + 642 WP_006247800.1 hypothetical protein -
BG607_RS09675 1866607..1867008 + 402 WP_006247801.1 hypothetical protein -
BG607_RS09680 1867053..1867283 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG607_RS09685 1867351..1867617 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG607_RS09690 1867621..1867890 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG607_RS09695 1867965..1868228 + 264 WP_006247805.1 hypothetical protein -
BG607_RS09700 1868288..1868998 + 711 WP_006253312.1 tape measure protein -
BG607_RS09705 1868976..1869266 + 291 Protein_1886 C40 family peptidase -
BG607_RS09710 1869256..1869975 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG607_RS09715 1870197..1870823 + 627 WP_006247807.1 tail assembly protein -
BG607_RS09720 1870872..1871483 + 612 WP_006253310.1 hypothetical protein -
BG607_RS09725 1871594..1872280 + 687 WP_006247808.1 hypothetical protein -
BG607_RS14050 1872290..1872448 + 159 WP_006247809.1 hypothetical protein -
BG607_RS09730 1872457..1872756 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1853444..1877518 24074
- flank IS/Tn - - 1862694..1863386 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67415 WP_006247804.1 NZ_CP017552:1867621-1867890 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67415 NZ_CP017552:1867621-1867890 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67415 WP_006247803.1 NZ_CP017552:1867351-1867617 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67415 NZ_CP017552:1867351-1867617 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References