Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1296926..1297574 Replicon chromosome
Accession NZ_CP017552
Organism Mannheimia haemolytica strain 1282

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG607_RS06705 Protein ID WP_006251221.1
Coordinates 1297398..1297574 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG607_RS06700 Protein ID WP_006251222.1
Coordinates 1296926..1297342 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG607_RS06660 1293228..1293662 + 435 WP_006251230.1 hypothetical protein -
BG607_RS06665 1293677..1294666 + 990 WP_006251229.1 encapsulin -
BG607_RS06670 1294678..1294929 + 252 WP_015484272.1 hypothetical protein -
BG607_RS06675 1294932..1295309 + 378 WP_006251227.1 hypothetical protein -
BG607_RS06680 1295309..1295653 + 345 WP_006251226.1 hypothetical protein -
BG607_RS06685 1295655..1296023 + 369 WP_006251225.1 hypothetical protein -
BG607_RS06690 1296020..1296400 + 381 WP_006251224.1 hypothetical protein -
BG607_RS06695 1296404..1296886 + 483 WP_006251223.1 phage tail protein -
BG607_RS06700 1296926..1297342 - 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG607_RS06705 1297398..1297574 - 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG607_RS06710 1297670..1298341 + 672 WP_006251220.1 hypothetical protein -
BG607_RS06715 1298356..1298589 - 234 WP_020824316.1 hypothetical protein -
BG607_RS06720 1298758..1299216 + 459 WP_006251218.1 hypothetical protein -
BG607_RS06730 1299761..1302256 + 2496 WP_006251216.1 phage tail length tape measure family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1295467..1472055 176588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67413 WP_006251221.1 NZ_CP017552:c1297574-1297398 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67413 NZ_CP017552:c1297574-1297398 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67413 WP_006251222.1 NZ_CP017552:c1297342-1296926 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67413 NZ_CP017552:c1297342-1296926 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References