67397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1085139..1085678 Replicon chromosome
Accession NZ_CP017550
Organism Mannheimia haemolytica strain 1309

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG589_RS05460 Protein ID WP_006247804.1
Coordinates 1085139..1085408 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG589_RS05465 Protein ID WP_006247803.1
Coordinates 1085412..1085678 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG589_RS05420 1080273..1080572 + 300 WP_006247810.1 XRE family transcriptional regulator -
BG589_RS14285 1080581..1080739 - 159 WP_006247809.1 hypothetical protein -
BG589_RS05425 1080749..1081435 - 687 WP_006247808.1 hypothetical protein -
BG589_RS05430 1081546..1082157 - 612 WP_006253310.1 hypothetical protein -
BG589_RS05435 1082206..1082832 - 627 WP_006247807.1 tail assembly protein -
BG589_RS05440 1083054..1083773 - 720 WP_006247806.1 preprotein translocase subunit YajC -
BG589_RS05445 1083763..1084053 - 291 Protein_1039 C40 family peptidase -
BG589_RS05450 1084031..1084741 - 711 WP_006253312.1 tape measure protein -
BG589_RS05455 1084801..1085064 - 264 WP_006247805.1 hypothetical protein -
BG589_RS05460 1085139..1085408 - 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG589_RS05465 1085412..1085678 - 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG589_RS05470 1085746..1085976 - 231 WP_006247802.1 DUF4035 domain-containing protein -
BG589_RS05475 1086021..1086422 - 402 WP_006247801.1 hypothetical protein -
BG589_RS05480 1086505..1087146 - 642 WP_006247800.1 hypothetical protein -
BG589_RS05485 1087178..1087573 - 396 WP_006247799.1 phage tail protein -
BG589_RS05490 1087598..1087825 - 228 Protein_1048 phage terminase large subunit family protein -
BG589_RS05495 1087975..1088349 + 375 WP_006247798.1 hypothetical protein -
BG589_RS05500 1088357..1088524 + 168 WP_006253314.1 DNA cytosine methyltransferase -
BG589_RS05505 1088605..1088928 + 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG589_RS05510 1088832..1089542 + 711 Protein_1052 tyrosine-type recombinase/integrase -
BG589_RS05520 1089643..1090278 + 636 Protein_1053 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1074085..1098291 24206
- flank IS/Tn - - 1089643..1090335 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67397 WP_006247804.1 NZ_CP017550:c1085408-1085139 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67397 NZ_CP017550:c1085408-1085139 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67397 WP_006247803.1 NZ_CP017550:c1085678-1085412 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67397 NZ_CP017550:c1085678-1085412 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References