Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1783665..1784204 Replicon chromosome
Accession NZ_CP017549
Organism Mannheimia haemolytica strain 1318

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG602_RS09145 Protein ID WP_006247804.1
Coordinates 1783935..1784204 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG602_RS09140 Protein ID WP_006247803.1
Coordinates 1783665..1783931 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG602_RS09085 1779065..1779700 - 636 Protein_1760 transposase -
BG602_RS09095 1779801..1780511 - 711 Protein_1761 tyrosine-type recombinase/integrase -
BG602_RS09100 1780415..1780738 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG602_RS09105 1780819..1780986 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG602_RS09110 1780994..1781368 - 375 WP_006247798.1 hypothetical protein -
BG602_RS09115 1781518..1781745 + 228 Protein_1765 phage terminase large subunit family protein -
BG602_RS09120 1781770..1782165 + 396 WP_006247799.1 phage tail protein -
BG602_RS09125 1782197..1782838 + 642 WP_006247800.1 hypothetical protein -
BG602_RS09130 1782921..1783322 + 402 WP_006247801.1 hypothetical protein -
BG602_RS09135 1783367..1783597 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG602_RS09140 1783665..1783931 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG602_RS09145 1783935..1784204 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG602_RS09150 1784279..1784542 + 264 WP_006247805.1 hypothetical protein -
BG602_RS09155 1784602..1785312 + 711 WP_006253312.1 tape measure protein -
BG602_RS09160 1785290..1785580 + 291 Protein_1774 C40 family peptidase -
BG602_RS09165 1785570..1786289 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG602_RS09170 1786511..1787137 + 627 WP_006247807.1 tail assembly protein -
BG602_RS09175 1787186..1787797 + 612 WP_006253310.1 hypothetical protein -
BG602_RS09180 1787908..1788594 + 687 WP_006247808.1 hypothetical protein -
BG602_RS14035 1788604..1788762 + 159 WP_006247809.1 hypothetical protein -
BG602_RS09185 1788771..1789070 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1771052..1841077 70025
- flank IS/Tn - - 1779008..1779700 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67391 WP_006247804.1 NZ_CP017549:1783935-1784204 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67391 NZ_CP017549:1783935-1784204 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67391 WP_006247803.1 NZ_CP017549:1783665-1783931 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67391 NZ_CP017549:1783665-1783931 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References