Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1563964..1564612 Replicon chromosome
Accession NZ_CP017549
Organism Mannheimia haemolytica strain 1318

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag BG602_RS07850 Protein ID WP_006251221.1
Coordinates 1563964..1564140 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag BG602_RS07855 Protein ID WP_006251222.1
Coordinates 1564196..1564612 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG602_RS07825 1559282..1561777 - 2496 WP_006251216.1 phage tail length tape measure family protein -
BG602_RS07835 1562322..1562780 - 459 WP_006251218.1 hypothetical protein -
BG602_RS07840 1562949..1563182 + 234 WP_020824316.1 hypothetical protein -
BG602_RS07845 1563197..1563868 - 672 WP_006251220.1 hypothetical protein -
BG602_RS07850 1563964..1564140 + 177 WP_006251221.1 type II toxin-antitoxin system HicA family toxin Toxin
BG602_RS07855 1564196..1564612 + 417 WP_006251222.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BG602_RS07860 1564652..1565134 - 483 WP_006251223.1 phage tail protein -
BG602_RS07865 1565138..1565518 - 381 WP_006251224.1 hypothetical protein -
BG602_RS07870 1565515..1565883 - 369 WP_006251225.1 hypothetical protein -
BG602_RS07875 1565885..1566229 - 345 WP_006251226.1 hypothetical protein -
BG602_RS07880 1566229..1566606 - 378 WP_006251227.1 hypothetical protein -
BG602_RS07885 1566609..1566842 - 234 WP_075271287.1 hypothetical protein -
BG602_RS07890 1566854..1567843 - 990 WP_006251229.1 encapsulin -
BG602_RS07895 1567858..1568292 - 435 WP_006251230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1530620..1597860 67240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T67389 WP_006251221.1 NZ_CP017549:1563964-1564140 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T67389 NZ_CP017549:1563964-1564140 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT67389 WP_006251222.1 NZ_CP017549:1564196-1564612 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT67389 NZ_CP017549:1564196-1564612 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A099

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZZL6

References