Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1874252..1874791 Replicon chromosome
Accession NZ_CP017546
Organism Mannheimia haemolytica strain 1342

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag BG592_RS09785 Protein ID WP_006247804.1
Coordinates 1874522..1874791 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag BG592_RS09780 Protein ID WP_006247803.1
Coordinates 1874252..1874518 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG592_RS09725 1869652..1870287 - 636 Protein_1879 transposase -
BG592_RS09735 1870388..1871098 - 711 Protein_1880 tyrosine-type recombinase/integrase -
BG592_RS09740 1871002..1871325 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
BG592_RS09745 1871406..1871573 - 168 WP_006253314.1 DNA cytosine methyltransferase -
BG592_RS09750 1871581..1871955 - 375 WP_006247798.1 hypothetical protein -
BG592_RS09755 1872105..1872332 + 228 Protein_1884 phage terminase large subunit family protein -
BG592_RS09760 1872357..1872752 + 396 WP_006247799.1 phage tail protein -
BG592_RS09765 1872784..1873425 + 642 WP_006247800.1 hypothetical protein -
BG592_RS09770 1873508..1873909 + 402 WP_006247801.1 hypothetical protein -
BG592_RS09775 1873954..1874184 + 231 WP_006247802.1 DUF4035 domain-containing protein -
BG592_RS09780 1874252..1874518 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG592_RS09785 1874522..1874791 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BG592_RS09790 1874866..1875129 + 264 WP_006247805.1 hypothetical protein -
BG592_RS09795 1875189..1875899 + 711 WP_006253312.1 tape measure protein -
BG592_RS09800 1875877..1876167 + 291 Protein_1893 C40 family peptidase -
BG592_RS09805 1876157..1876876 + 720 WP_006247806.1 preprotein translocase subunit YajC -
BG592_RS09810 1877098..1877724 + 627 WP_006247807.1 tail assembly protein -
BG592_RS09815 1877773..1878384 + 612 WP_006253310.1 hypothetical protein -
BG592_RS09820 1878495..1879181 + 687 WP_006247808.1 hypothetical protein -
BG592_RS14125 1879191..1879349 + 159 WP_006247809.1 hypothetical protein -
BG592_RS09825 1879358..1879657 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1861639..1885845 24206
- flank IS/Tn - - 1869595..1870287 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T67368 WP_006247804.1 NZ_CP017546:1874522-1874791 [Mannheimia haemolytica]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T67368 NZ_CP017546:1874522-1874791 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT67368 WP_006247803.1 NZ_CP017546:1874252-1874518 [Mannheimia haemolytica]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT67368 NZ_CP017546:1874252-1874518 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References