Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
Location | 2488502..2489024 | Replicon | chromosome |
Accession | NZ_CP017544 | ||
Organism | Mannheimia haemolytica strain 1373 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A248ZX63 |
Locus tag | BG581_RS12970 | Protein ID | WP_006250322.1 |
Coordinates | 2488502..2488771 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | A0A248ZY54 |
Locus tag | BG581_RS12975 | Protein ID | WP_006250323.1 |
Coordinates | 2488758..2489024 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BG581_RS12950 | 2483822..2484256 | - | 435 | WP_006250318.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
BG581_RS12955 | 2484231..2485076 | - | 846 | WP_006250319.1 | virulence factor BrkB family protein | - |
BG581_RS12960 | 2485078..2486316 | - | 1239 | WP_006250320.1 | glutamate-5-semialdehyde dehydrogenase | - |
BG581_RS12965 | 2486600..2488483 | + | 1884 | WP_006250321.1 | DNA mismatch repair endonuclease MutL | - |
BG581_RS12970 | 2488502..2488771 | - | 270 | WP_006250322.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
BG581_RS12975 | 2488758..2489024 | - | 267 | WP_006250323.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
BG581_RS12980 | 2489464..2490417 | + | 954 | WP_006250325.1 | tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA | - |
BG581_RS12985 | 2490486..2490758 | + | 273 | WP_006250326.1 | RNA chaperone Hfq | - |
BG581_RS12990 | 2490778..2492163 | + | 1386 | WP_006253648.1 | GTPase HflX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10447.99 Da Isoelectric Point: 6.4732
>T67354 WP_006250322.1 NZ_CP017544:c2488771-2488502 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG
Download Length: 270 bp
>T67354 NZ_CP017544:c2488771-2488502 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9738.10 Da Isoelectric Point: 4.7954
>AT67354 WP_006250323.1 NZ_CP017544:c2489024-2488758 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD
Download Length: 267 bp
>AT67354 NZ_CP017544:c2489024-2488758 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A248ZX63 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A248ZY54 |